Denver Public Health, Denver Health and Hospital Authority, Denver, Colorado; Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado.
Division of Substance Dependence, University of Colorado School of Medicine, Aurora, Colorado.
J Adolesc Health. 2018 Feb;62(2):241-244. doi: 10.1016/j.jadohealth.2017.09.018. Epub 2017 Nov 22.
We sought to describe the prevalence of the nonmedical use of prescription opioids (NMUPO) and its association with co-occurring substance use disorders in a sample of adolescents in substance treatment.
Adolescents in two substance treatment programs were recruited for participation between 2009 and 2013. The Composite International Diagnostic Interview-Substance Abuse Module (CIDI-SAM) was administered to assess substance use patterns and lifetime abuse or dependence.
A total of 378 adolescents completed the CIDI-SAM (mean age 16.1 [standard deviation = 1.1], 78% male, 50% white, non-Hispanic). Of the 378 adolescents, 62 (16.4%) reported NMUPO and 59 (15.6%) were diagnosed with opioid/heroin abuse or dependence. The mean age at first NMUPO was 14.3 (standard deviation = 1.4). NMUPO was associated with a 3.31-fold (95% confidence interval: 2.83-3.79) increase in having three or more co-occurring substance use diagnoses.
NMUPO is quite prevalent among adolescents in substance use treatment. Intervention to interrupt NMUPO from progressing to heroin use or developing into a disorder is critical.
我们旨在描述在接受物质治疗的青少年样本中，非医疗用途处方阿片类药物（NMUPO）的流行情况及其与同时存在的物质使用障碍的关联。
2009 年至 2013 年间，我们招募了两个物质治疗项目的青少年参与研究。采用复合国际诊断访谈-物质滥用模块（CIDI-SAM）评估物质使用模式和终身滥用或依赖情况。
共有 378 名青少年完成了 CIDI-SAM（平均年龄 16.1 [标准差=1.1]，78%为男性，50%为白人，非西班牙裔）。在 378 名青少年中，有 62 名（16.4%）报告存在 NMUPO，59 名（15.6%）被诊断为阿片类药物/海洛因滥用或依赖。首次 NMUPO 的平均年龄为 14.3（标准差=1.4）。NMUPO 与同时存在三种或更多种物质使用障碍诊断的风险增加 3.31 倍（95%置信区间：2.83-3.79）。
NMUPO 在接受物质治疗的青少年中相当普遍。干预措施以阻止 NMUPO 进展为海洛因使用或发展为障碍至关重要。
