Tabei K, Furuya H, Asano Y, Hosoda S
Department of Medicine, Jichi Medical School, Tochigi, Japan.
Eur J Clin Pharmacol. 1989;36(1):83-6. doi: 10.1007/BF00561030.
The effect of short- and long-term administration of carteolol on renal function has been examined in healthy subjects and in hypertensive patients with or without renal failure. In healthy subjects neither a single dose of 10 mg carteolol nor continuous administration of 20 mg/day for 7 days had any effect on creatinine clearance and renal blood flow. In all subjects the clearance rate of carteolol was about 400 ml/min and its fractional excretion of carteolol exceeded 300%, suggesting that the drug is secreted actively from renal tubules. Twenty-three hypertensive patients with or without renal dysfunction were given carteolol 10 to 20 mg/day for more than 50 weeks in addition to their standard antihypertensive regimens, which were left changed. Laboratory results were compared with the mean values of 50 weeks before and after the addition of carteolol, and none, including plasma creatinine, blood urea nitrogen and electrolytes, were significantly changed. Neither the estimated glomerular filtration rate nor the effect of the drug on blood pressure changed significantly during this prolonged treatment. It is concluded that carteolol had no effect on renal function in healthy subjects and in hypertensive patients with or without renal failure.
已在健康受试者以及患有或未患肾衰竭的高血压患者中研究了短期和长期服用卡替洛尔对肾功能的影响。在健康受试者中，单次服用10mg卡替洛尔或连续7天每天服用20mg均对肌酐清除率和肾血流量无任何影响。在所有受试者中，卡替洛尔的清除率约为400ml/分钟，其卡替洛尔的分数排泄超过300%，表明该药物是从肾小管主动分泌的。23名患有或未患肾功能不全的高血压患者，除维持其不变的标准抗高血压治疗方案外，每天给予10至20mg卡替洛尔，持续超过50周。将实验室结果与加用卡替洛尔之前和之后50周的平均值进行比较，包括血浆肌酐、血尿素氮和电解质在内，均无显著变化。在这种长期治疗期间，估计的肾小球滤过率以及药物对血压的影响均未发生显著变化。得出的结论是，卡替洛尔对健康受试者以及患有或未患肾衰竭的高血压患者的肾功能均无影响。
