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比较微计算机断层扫描和组织形态计量学评价聚醚醚酮涂层钛植入物在大鼠模型中的骨整合。

A comparison of micro-CT and histomorphometry for evaluation of osseointegration of PEO-coated titanium implants in a rat model.

机构信息

Department of Orthopedics, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P.R. China.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, P.R. China.

出版信息

Sci Rep. 2017 Nov 24;7(1):16270. doi: 10.1038/s41598-017-16465-4.

DOI:10.1038/s41598-017-16465-4
PMID:29176604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5701240/
Abstract

The aim of the present study was to determine the correlation between bone volume density (BV/TV) around a titanium implant determined by micro-computed tomography (micro-CT) and bone area density (BA/TA) measurements obtained using histomorphometry. An intramedullary rat femur implant model was evaluated to compare raw titanium implants with plasma electrolytic oxidation (PEO)-coated titanium implants. Titanium and PEO-treated titanium pins were inserted into rat femurs under general anesthesia. The animals were sacrificed and femurs harvested at 0, 2, 4 and 6 weeks, and subsequently, histomorphometry and micro-CT were performed. BV/TV and BA/TA values were strongly and positively correlated at all time points and locations (with all correlation coefficients being >0.8 and with P < 0.001). BV/TV and BA/TA were significantly higher proximal to the growth plate than distal to the growth plate, with estimated differences of 14.10% (P < 0.001) and 11.95% (P < 0.001), respectively. BV/TV and BA/TA were significantly higher on the PEO-coated surface than on the raw titanium surface, with estimated differences of 3.20% (P = 0.044) and 4.10% (P = 0.018), respectively. Therefore, quantitative micro-CT analysis of BV/TV is correlated with BA/TA determined by histomorphometry when artifacts around titanium implants are minimized by a region of interest modification.

摘要

本研究旨在确定微计算机断层扫描（micro-CT）测定的钛种植体周围骨体积密度（BV/TV）与组织形态计量学获得的骨面积密度（BA/TA）测量值之间的相关性。评估了一种髓内大鼠股骨植入模型，以比较原始钛植入物和等离子电解氧化（PEO）涂层钛植入物。在全身麻醉下将钛和 PEO 处理的钛针插入大鼠股骨。在 0、2、4 和 6 周时处死动物并收获股骨，随后进行组织形态计量学和 micro-CT 检查。在所有时间点和位置，BV/TV 和 BA/TA 值均呈强正相关（所有相关系数均>0.8，P<0.001）。与生长板远端相比，生长板近端的 BV/TV 和 BA/TA 值显著更高，估计差异分别为 14.10%（P<0.001）和 11.95%（P<0.001）。PEO 涂层表面的 BV/TV 和 BA/TA 值明显高于原始钛表面，估计差异分别为 3.20%（P=0.044）和 4.10%（P=0.018）。因此，当通过感兴趣区域修改最小化钛植入物周围的伪影时，BV/TV 的定量 micro-CT 分析与组织形态计量学确定的 BA/TA 相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7aa/5701240/a8a09c11d962/41598_2017_16465_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7aa/5701240/f39463beab35/41598_2017_16465_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7aa/5701240/f7446f42a245/41598_2017_16465_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7aa/5701240/2ac05d677602/41598_2017_16465_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7aa/5701240/2cbc5d55db7d/41598_2017_16465_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7aa/5701240/835c77a72e09/41598_2017_16465_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7aa/5701240/67d0a425ef2c/41598_2017_16465_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7aa/5701240/a8a09c11d962/41598_2017_16465_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7aa/5701240/f39463beab35/41598_2017_16465_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7aa/5701240/f7446f42a245/41598_2017_16465_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7aa/5701240/2ac05d677602/41598_2017_16465_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7aa/5701240/2cbc5d55db7d/41598_2017_16465_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7aa/5701240/835c77a72e09/41598_2017_16465_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7aa/5701240/67d0a425ef2c/41598_2017_16465_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7aa/5701240/a8a09c11d962/41598_2017_16465_Fig7_HTML.jpg

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