Department of Diagnosis and Surgery, School of Dentistry of Araraquara, São Paulo State University (UNESP), Araraquara, Brazil.
Department of Periodontology and Implantology, School of Dentistry at Uberlândia, Federal University of Uberlândia, Uberlândia, Brazil.
Clin Oral Investig. 2024 Jan 13;28(1):89. doi: 10.1007/s00784-023-05480-7.
To evaluate the osseointegration of implants with hydrophobic (HFB) and hydrophilic (HFL) surfaces in a murine model of high-dose bisphosphonates (BPs).
Sixty-four rats were randomly allocated into four groups: control group with HFB implants (CG-HFB), control group with HFL implants (CG-HFL), BP group with HFB implants (BP-HFB), and BP group with HFL implants (BP-HFL). Animals were euthanized after 15 and 45 days (n=8). The dependent variables assessed were the removal torque (biomechanical analysis), the bone volume around the implants (%BV/TV) (microtomographic analysis), the bone-implant contact (%BIC), the bone between the threads (%BBT) (histomorphometric analysis), and the expression of bone metabolism markers (immunohistochemistry analysis).
The CG-HFL and BP-HFL groups presented higher removal torque than the CG-HFB and BP-HFB implants. The %BIC of the CG-HFL surfaces was slightly higher than that of the CG-HFB implants. The BP-HFB and BP-HFL groups presented a higher %BIC than that of the CG-HFB and CG-HFL groups (p<0.001). BP therapy also increased the %BBT at both implant surfaces. Higher levels of ALP were observed in the matrix region of bone tissue on the HFL surfaces than on the HFB surfaces.
Both surfaces enable osseointegration in rats under BP therapy.
The study demonstrates that hydrophobic (HFB) and hydrophilic (HFL) implant surfaces can promote osseointegration in rats undergoing bisphosphonate therapy. The HFL surfaces exhibited improved biomechanical performance, higher bone-implant contact, and increased bone volume, suggesting their potential clinical relevance for implant success in individuals on bisphosphonate treatment.
评估在高剂量双膦酸盐（BP）小鼠模型中具有疏水性（HFB）和亲水性（HFL）表面的种植体的骨整合情况。
将 64 只大鼠随机分配到 4 个组：HFB 种植体的对照组（CG-HFB）、HFL 种植体的对照组（CG-HFL）、HFB 种植体的 BP 组（BP-HFB）和 HFL 种植体的 BP 组（BP-HFL）。15 天和 45 天（每组 8 只）后处死动物。评估的依赖变量包括：（生物力学分析）拔出扭矩、种植体周围骨体积（%BV/TV）（微断层扫描分析）、骨-种植体接触（%BIC）、螺纹间骨（%BBT）（组织形态计量分析）和骨代谢标志物的表达（免疫组织化学分析）。
CG-HFL 和 BP-HFL 组的拔出扭矩均高于 CG-HFB 和 BP-HFB 种植体。CG-HFL 表面的 %BIC 略高于 CG-HFB 种植体。BP-HFB 和 BP-HFL 组的 %BIC 均高于 CG-HFB 和 CG-HFL 组（p<0.001）。BP 治疗还增加了两种种植体表面的 %BBT。在 HFL 表面的骨组织基质区域观察到较高水平的碱性磷酸酶。
在 BP 治疗的大鼠中，两种表面均能实现骨整合。
该研究表明，疏水性（HFB）和亲水性（HFL）种植体表面可促进接受双膦酸盐治疗的大鼠的骨整合。HFL 表面表现出更好的生物力学性能、更高的骨-种植体接触和增加的骨量，这表明它们在接受双膦酸盐治疗的个体中对种植体成功具有潜在的临床相关性。
