Ronay G, Jäger W, Tulusan A H
Frauenklinik mit Poliklinik der Universität Erlangen-Nürnberg.
Geburtshilfe Frauenheilkd. 1989 Jan;49(1):61-3. doi: 10.1055/s-2008-1035738.
We report on two young patients with massively elevated CA-125 serum level of 290 and 264 U/ml respectively, who clinically exhibited suddenly occurring ascites. The diagnosis of ovarian carcinoma or ruptured ovarian cystoma led to a laparotomy. During the operation, a disseminating granulomatous inflammation was evident, which was identified histologically and microbiologically as miliary tuberculosis with peritoneal invasion. CA-125 was immunohistochemically localised, sharply demarcated around the tuberculous granuloma. A possible explanation for this finding is the inflammatory mesothelial proliferation. A similarity in antigenic structures of membrane components of M. tuberculosis and CA-125 cannot be excluded. Serum CA-125 levels tested 6 months after the treatment of the tuberculosis showed a value within the normal range (less than 35 U/ml).
我们报告了两名年轻患者，其血清CA - 125水平分别大幅升高至290和264 U/ml，临床上均突然出现腹水。卵巢癌或破裂的卵巢囊肿的诊断导致了剖腹手术。手术过程中，可见弥漫性肉芽肿性炎症，经组织学和微生物学鉴定为粟粒性结核伴腹膜侵犯。CA - 125通过免疫组织化学定位，在结核肉芽肿周围界限清晰。这一发现的一个可能解释是炎症性间皮增生。不能排除结核分枝杆菌膜成分与CA - 125抗原结构的相似性。抗结核治疗6个月后检测的血清CA - 125水平显示在正常范围内（低于35 U/ml）。
