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成人退行性脊柱侧凸短节段融合与长节段融合的疗效:一项系统评价和荟萃分析。

Outcomes of Short Fusion versus Long Fusion for Adult Degenerative Scoliosis: A Systematic Review and Meta-analysis.

作者信息

Phan Kevin, Xu Joshua, Maharaj Monish M, Li Julian, Kim Jun S, Di Capua John, Somani Sulaiman, Tan Kimberly-Anne, Mobbs Ralph J, Cho Samuel K

机构信息

NeuroSpine Surgery Research Group (NSURG), Prince of Wales Private Hospital, Sydney, Australia.

Faculty of Medicine, University of New South Wales (UNSW), Sydney, Australia.

出版信息

Orthop Surg. 2017 Nov;9(4):342-349. doi: 10.1111/os.12357.

Abstract

The objective of this study was to evaluate differences in clinical and radiographic outcomes between short (<3 levels) and long (≥3 levels) fusions in the setting of degenerative lumbar scoliosis. A literature search was performed from six electronic databases. The key terms of "degenerative scoliosis" OR "lumbar scoliosis" AND "fusion" were combined and used as MeSH subheadings. From relevant studies identified, demographic data, complication rates, Oswestry Disability Index (ODI), and radiographic parameters were extracted and the data was pooled and analyzed. Long fusion was associated with comparable overall complication rates to short fusion (17% vs 14%, P = 0.20). There was a significant difference in the incidence of pulmonary complications when comparing short versus long fusion (0.42% vs 2.70%; P = 0.02). No significant difference was found in terms of motor, sensory complications, infections, construct-related or cardiac complications, pseudoarthrosis, dural tears, cerebrospinal fluid (CSF) leak, or urinary retention. A longer fusion was associated with a greater reduction in coronal Cobb angle and increases in lumbar lordosis, but both findings failed to achieve statistical significance. The ODI was comparable across both cohorts. If shorter fusion lengths are clinically indicated, they should be used instead of longer fusion lengths to reduce perioperative time, costs, and some other complications. However, there are no statistically significant differences in terms of radiographically measurable restoration associated with a short or long fusion.

摘要

本研究的目的是评估退行性腰椎侧凸患者短节段(<3个节段)融合与长节段(≥3个节段)融合在临床和影像学结果上的差异。通过六个电子数据库进行文献检索。将“退行性脊柱侧凸”或“腰椎脊柱侧凸”与“融合”的关键词组合并用作医学主题词表副主题词。从已确定的相关研究中提取人口统计学数据、并发症发生率、Oswestry功能障碍指数(ODI)和影像学参数,并对数据进行汇总和分析。长节段融合的总体并发症发生率与短节段融合相当(17%对14%,P = 0.20)。比较短节段融合与长节段融合时,肺部并发症的发生率存在显著差异(0.42%对2.70%;P = 0.02)。在运动、感觉并发症、感染、植入物相关或心脏并发症、假关节形成、硬脊膜撕裂、脑脊液(CSF)漏或尿潴留方面未发现显著差异。更长节段的融合与冠状面Cobb角的更大减小和腰椎前凸的增加相关,但这两个结果均未达到统计学显著性。两个队列的ODI相当。如果临床上表明需要较短的融合长度,则应使用较短的融合长度而非较长的融合长度,以减少围手术期时间、成本和其他一些并发症。然而,短节段融合与长节段融合在影像学可测量的恢复方面没有统计学上的显著差异。

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