Department of Experimental Medicine, Section of Pharmacology "L. Donatelli", University of Campania Region "Luigi Vanvitelli", Naples, Italy.
Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence, Florence, Italy.
Int J Cardiol. 2018 Feb 1;252:181-186. doi: 10.1016/j.ijcard.2017.11.075. Epub 2017 Nov 23.
Hypertension is an important global health challenge and a leading preventable risk factor for premature death and disability worldwide. In current cardiology practice, the main obstacles in the management of patients affected by hypertension are comorbidities and poor adherence to pharmacological treatments. The World Health Organization has recently highlighted increased adherence as a key development need for reducing cardiovascular disease.
Principal observational and clinical trial data regarding adherence, reductions in cardiovascular risk and safety of the polypill approach are summarized and reviewed.
The polypill approach has been conclusively shown to increase adherence relative to usual care in all cardiovascular patients, furthermore, concomitant risk factor reductions have also been suggested. To date, the use of polypill could represent a solution strategy in patients affected by hypertension, comorbidities and non-adherence even though further studies, especially in the real-world settings, are needed in order to better understand its role in clinical practice.
高血压是一个重要的全球健康挑战，也是全球范围内导致过早死亡和残疾的主要可预防风险因素。在当前的心脏病学实践中，管理高血压患者的主要障碍是合并症和药物治疗的依从性差。世界卫生组织最近强调，提高依从性是减少心血管疾病的一个关键发展需求。
总结和回顾了关于依从性、心血管风险降低和复方药物治疗方法安全性的主要观察性和临床试验数据。
复方药物治疗方法已被明确证明可提高所有心血管病患者相对于常规护理的依从性，此外，还提示了伴随的危险因素降低。迄今为止，尽管还需要进一步的研究，特别是在真实世界环境中，以更好地了解其在临床实践中的作用，但复方药物治疗方法的使用可能是高血压、合并症和不依从患者的一种解决方案策略。
