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本文引用的文献

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Hepatocyte Growth Factor Mediates Enhanced Wound Healing Responses and Resistance to Transforming Growth Factor-β₁-Driven Myofibroblast Differentiation in Oral Mucosal Fibroblasts.肝细胞生长因子介导口腔黏膜成纤维细胞增强伤口愈合反应并抵抗转化生长因子-β₁驱动的肌成纤维细胞分化。
Int J Mol Sci. 2017 Aug 24;18(9):1843. doi: 10.3390/ijms18091843.
2
Hepatocyte Growth Factor Suppresses Inflammation and Promotes Epithelium Repair in Corneal Injury.肝细胞生长因子抑制角膜损伤中的炎症并促进上皮修复。
Mol Ther. 2017 Aug 2;25(8):1881-1888. doi: 10.1016/j.ymthe.2017.04.020. Epub 2017 May 11.
3
Piceatannol increases the expression of hepatocyte growth factor and IL-10 thereby protecting hepatocytes in thioacetamide-induced liver fibrosis.白皮杉醇可增加肝细胞生长因子和白细胞介素-10的表达，从而在硫代乙酰胺诱导的肝纤维化中保护肝细胞。
Can J Physiol Pharmacol. 2016 Jul;94(7):779-87. doi: 10.1139/cjpp-2016-0001. Epub 2016 Mar 5.
4
The corneal fibrosis response to epithelial-stromal injury.角膜对上皮-基质损伤的纤维化反应。
Exp Eye Res. 2016 Jan;142:110-8. doi: 10.1016/j.exer.2014.09.012.
5
Epipolis-laser in situ keratomileusis versus photorefractive keratectomy for the correction of myopia: a meta-analysis.用于矫正近视的角膜上皮下准分子原位角膜磨镶术与准分子激光角膜切削术对比：一项荟萃分析
Int Ophthalmol. 2015 Oct;35(5):757-63. doi: 10.1007/s10792-015-0109-z. Epub 2015 Aug 8.
6
Effect of matrine on transforming growth factor β1 and hepatocyte growth factor in rat liver fibrosis model.苦参碱对大鼠肝纤维化模型中转化生长因子β1和肝细胞生长因子的影响
Asian Pac J Trop Med. 2014 May;7(5):390-3. doi: 10.1016/S1995-7645(14)60062-6.
7
Hepatocyte growth factor regulates the TGF-β1-induced proliferation, differentiation and secretory function of cardiac fibroblasts.肝细胞生长因子调节转化生长因子-β1诱导的心脏成纤维细胞的增殖、分化和分泌功能。
Int J Mol Med. 2014 Aug;34(2):381-90. doi: 10.3892/ijmm.2014.1782. Epub 2014 May 16.
8
Hepatocyte growth factor and basic fibroblast growth factor regulate atrial fibrosis in patients with atrial fibrillation and rheumatic heart disease via the mitogen-activated protein kinase signaling pathway.肝细胞生长因子和碱性成纤维细胞生长因子通过丝裂原活化蛋白激酶信号通路调节心房颤动和风湿性心脏病患者的心房纤维化。
Exp Ther Med. 2013 Nov;6(5):1121-1126. doi: 10.3892/etm.2013.1274. Epub 2013 Aug 28.
9
Comparison of TGF-β1 in tears and corneal haze following Epi-LASIK with and without mitomycin C.准分子激光上皮下角膜磨镶术（Epi-LASIK）联合与不联合丝裂霉素C后泪液和角膜混浊中转化生长因子-β1（TGF-β1）的比较
Int J Ophthalmol. 2013 Jun 18;6(3):312-5. doi: 10.3980/j.issn.2222-3959.2013.03.10. Print 2013.
10
Human Wharton's jelly-derived mesenchymal stromal cells reduce renal fibrosis through induction of native and foreign hepatocyte growth factor synthesis in injured tubular epithelial cells.人脐带华通氏胶间充质基质细胞通过诱导损伤的肾小管上皮细胞合成内源性和外源性肝细胞生长因子来减轻肾纤维化。
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[兔表层角膜切削准分子原位角膜磨镶术后早期泪液中肝细胞生长因子与角膜混浊的关系]

[Association between hepatocyte growth factor in tears and corneal haze in rabbits early after epipolis laser in situ keratomileusis].

作者信息

Chen Jing, Han Su-Ning, Zou Xiu-Lan, Zou Yu-Ping

机构信息

Department of Ophthalmology, Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010, China. E-mail:

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2017 Nov 20;37(11):1551-1554. doi: 10.3969/j.issn.1673-4254.2017.11.21.

DOI:10.3969/j.issn.1673-4254.2017.11.21
PMID:29180340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6779644/
Abstract

OBJECTIVE

To study the dynamic changes of levels of hepatocyte growth factor (HGF) in tears and their association with corneal haze in rabbits early after epipolis laser in situ keratomileusis (Epi-LASIK).

METHODS

Twenty-four New Zealand rabbits received Epi-LASIK with an ablation depth of 100 µm in one eye and of 150 µm in the other eye. Before and at 3, 7, 14, and 30 days after the surgery, the level of HGF in tears collected from the rabbits was measured using enzyme-linked immunosorbent assay (ELISA), and corneal haze was graded after surgery.

RESULTS

In all the rabbits, corneal epithelium healing occurred in 3 to 5 days after Epi-LASIK. Corneal haze appeared 3 days postoperatively in the rabbits accompanied by increased levels of HGF in tears. At 3, 7, 14, and 30 days after the surgery, the rabbits with an ablation depth of 150 µm showed more obvious corneal haze (P<0.05) and significantly higher levels of HGF in tears than those with an ablation depth of 100 µm (P<0.05).

CONCLUSION

In rabbits receiving Epi-LASIK, HGF levels in tears and the grade of corneal haze show a positive correlation early after the surgery and are both related with the depth of ablation.

摘要

目的

研究兔表层角膜镜片式准分子原位角膜磨镶术（Epi-LASIK）术后早期泪液中肝细胞生长因子（HGF）水平的动态变化及其与角膜 haze 的关系。

方法

24 只新西兰兔，一只眼行 Epi-LASIK，消融深度为 100μm，另一只眼消融深度为 150μm。手术前及术后 3、7、14 和 30 天，采用酶联免疫吸附测定（ELISA）法检测兔泪液中 HGF 水平，并在术后对角膜 haze 进行分级。

结果

所有兔在 Epi-LASIK 术后 3 至 5 天角膜上皮愈合。术后 3 天兔出现角膜 haze，同时泪液中 HGF 水平升高。术后 3、7、14 和 30 天，消融深度为 150μm 的兔角膜 haze 更明显（P<0.05），泪液中 HGF 水平显著高于消融深度为 100μm 的兔（P<0.05）。

结论

接受 Epi-LASIK 的兔术后早期泪液中 HGF 水平与角膜 haze 分级呈正相关，且均与消融深度有关。