The Francis Crick Institute, London, UK.
Nat Neurosci. 2018 Jan;21(1):29-32. doi: 10.1038/s41593-017-0023-y. Epub 2017 Nov 27.
Excitation of accumbal D2 cells governs vital actions, including avoidance of learned risks, but the origins of this excitation and roles of D2 cells in innate risk-avoidance are unclear. Hypothalamic neurons producing orexins (also called hypocretins) enhance innate risk-avoidance via poorly understood neurocircuits. We describe a direct orexin→D2 excitatory circuit and show that D2 cell activity is necessary for orexin-dependent innate risk-avoidance in mice, thus revealing an unsuspected hypothalamus-accumbens interplay in action selection.
伏隔核 D2 细胞的兴奋控制着重要的行为，包括避免习得性风险，但这种兴奋的起源和 D2 细胞在先天风险回避中的作用尚不清楚。产生食欲素（也称为下丘脑泌素）的下丘脑神经元通过尚不清楚的神经回路增强先天风险回避。我们描述了一个直接的食欲素→D2 兴奋性回路，并表明 D2 细胞活性对于食欲素依赖性小鼠先天风险回避是必需的，从而揭示了在行为选择中一个意想不到的下丘脑-伏隔核相互作用。
