Department of Pharmacology and Shanghai Key Laboratory of Bioactive Small Molecules, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.
Neural Plast. 2017;2017:5870735. doi: 10.1155/2017/5870735. Epub 2017 Oct 18.
Depression, which is characterized by a pervasive and persistent low mood and anhedonia, greatly impacts patients, their families, and society. The associated and recurring sleep disturbances further reduce patient's quality of life. However, therapeutic sleep deprivation has been regarded as a rapid and robust antidepressant treatment for several decades, which suggests a complicated role of sleep in development of depression. Changes in neural plasticity are observed during physiological sleep, therapeutic sleep deprivation, and depression. This correlation might help us to understand better the mechanism underlying development of depression and the role of sleep. In this review, we first introduce the structure of sleep and the facilitated neural plasticity caused by physiological sleep. Then, we introduce sleep disturbances and changes in plasticity in patients with depression. Finally, the effects and mechanisms of antidepressants and therapeutic sleep deprivation on neural plasticity are discussed.
抑郁症的特征是普遍且持续的情绪低落和快感缺失，极大地影响了患者、他们的家庭和社会。相关的反复发作的睡眠障碍进一步降低了患者的生活质量。然而，几十年来，治疗性睡眠剥夺一直被视为一种快速而有效的抗抑郁治疗方法，这表明睡眠在抑郁症的发展中起着复杂的作用。在生理睡眠、治疗性睡眠剥夺和抑郁症期间观察到神经可塑性的变化。这种相关性可能有助于我们更好地理解抑郁症发展的机制以及睡眠的作用。在这篇综述中，我们首先介绍睡眠的结构和生理睡眠引起的促进神经可塑性。然后，我们介绍抑郁症患者的睡眠障碍和可塑性变化。最后，讨论了抗抑郁药和治疗性睡眠剥夺对神经可塑性的影响及其机制。
