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儿童原发性骨骺和干骺端结核性骨髓炎:8例系列报道

Primary epiphyseal and metaepiphyseal tubercular osteomyelitis in children A series of 8 case.

作者信息

Agarwal A, Gupta N, Mishra M, Agrawal N, Kumar D

出版信息

Acta Orthop Belg. 2016 Dec;82(4):797-805.

Abstract

UNLABELLED

Clinical series of primary epiphyseal and metaepiphyseal tubercular osteomyelitis are few. The purpose of our study was to retrospectively review the presentation, healing response and functional results of 8 such cases in children.

MATERIAL AND METHODS

The patients were evaluated for pain, deformity, range of motion, limb length discrepancy (if any) and recurrence. Serial radiographs of the region were studied to see remineralization, obliteration of radiological lesions, status of physis and remodeling of the growth plate.

RESULTS

The mean patient age was 7.1 years. Average follow up was 3.7 years. The mean duration of symptom before presentation was 2.9 months (range, 0.5-8 months). Knee region was involved in 4, distal radius in 2, shoulder and distal fibula in 1 patient each. The lesions were either localized or diffuse depending upon physeal involvement and osseous destruction. At the last follow up, the involved joints were painfree and had useful range of motion. Limb length lengthening was seen in all knee patients. The diffuse variety resulted in premature physeal closure. The residual lucencies persisted for several years without any clinical manifestations.

CONCLUSIONS

Primary epiphyseal and metaepiphyseal tuberculosis was relatively uncommon. The clinical outcome was good following curettage and multidrug antitubercular therapy. The epiphyseal and metaphyseal lucencies persisted for several months even after successful treatment. The diffuse variety lead to premature physeal closure. Limb length lengthening was common sequelae of tuberculosis of knee region.

摘要

未标注

原发性骨骺和干骺端结核性骨髓炎的临床病例系列较少。我们研究的目的是回顾性分析8例儿童此类病例的表现、愈合反应及功能结果。

材料与方法

对患者进行疼痛、畸形、活动范围、肢体长度差异(如有)及复发情况的评估。对该区域的系列X线片进行研究,以观察再矿化、放射学病变的消失、骨骺状态及生长板的重塑。

结果

患者平均年龄为7.1岁。平均随访时间为3.7年。就诊前症状的平均持续时间为2.9个月(范围0.5 - 8个月)。膝关节区域受累4例,桡骨远端受累2例,肩关节和腓骨远端各受累1例。根据骨骺受累及骨质破坏情况,病变可为局限性或弥漫性。在最后一次随访时,受累关节无疼痛且活动范围良好。所有膝关节患者均出现肢体长度延长。弥漫性病变导致骨骺过早闭合。残留的透亮区持续数年且无任何临床表现。

结论

原发性骨骺和干骺端结核相对少见。刮除术及多药抗结核治疗后临床结果良好。即使治疗成功,骨骺和干骺端的透亮区仍会持续数月。弥漫性病变导致骨骺过早闭合。肢体长度延长是膝关节结核的常见后遗症。

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