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儿童骨关节结核:综述

Paediatric osteoarticular tuberculosis: A review.

作者信息

Agarwal Anil

机构信息

Department of Paediatric Orthopaedics, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi, 110031, India.

出版信息

J Clin Orthop Trauma. 2020 Mar-Apr;11(2):202-207. doi: 10.1016/j.jcot.2020.01.005. Epub 2020 Jan 22.

Abstract

OBJECTIVE

Tuberculosis (TB) is endemic in Indian subcontinent. The paediatric osteoarticular (OA) TB is frequently confused with suppurative etiology as both can have similar clinical, radiological and laboratory presentation. It has become a health hazard due to its association with immunosuppression diseases such as HIV, chronic renal and liver diseases and use of immunosuppressive drugs. Furthermore, there is much dilemma regarding the drug choice and duration of anti tubercular treatment among practicing clinicians. This mini review briefs the reader to the classical regional and atypical tubercular clinical presentations, imaging and laboratory investigations and management for bone and joint TB.

METHODS

The article details both common and atypical clinical tubercular presentations, the approach to diagnosis, drug treatment and surgical indications in paediatric OA TB.

RESULTS

OA TB in the paediatric age group is uncommon. Diagnosis is often delayed because of diseases' nonspecific symptoms, non-characteristic imaging findings and lack of awareness of the condition. Multidrug antitubercular chemotherapy remains the anchor sheet of tubercular treatment in children. Surgery is needed in select cases to obtain tissue, to ensure better joint movement, prevent deformities and restore neurological function.

CONCLUSIONS

TB can have varied presentation and therefore it is essential to keep tubercular infection in differential diagnosis while working up for any infective pathology. Conservative treatment produces good results in vast majority of cases. Surgery is reserved for select indications.

摘要

目的

结核病在印度次大陆呈地方性流行。儿童骨关节炎(OA)型结核病常与化脓性病因相混淆,因为两者可能具有相似的临床、放射学和实验室表现。由于其与免疫抑制性疾病(如艾滋病、慢性肾和肝病)以及免疫抑制药物的使用有关,它已成为一种健康危害。此外,执业临床医生在抗结核治疗的药物选择和疗程方面存在诸多困惑。这篇小型综述向读者简要介绍了骨与关节结核的典型局部和非典型结核临床表现、影像学和实验室检查以及治疗方法。

方法

本文详细介绍了儿童OA型结核病常见和非典型的临床结核表现、诊断方法、药物治疗和手术指征。

结果

儿童年龄组的OA型结核病并不常见。由于疾病的非特异性症状、非特征性影像学表现以及对该疾病缺乏认识,诊断往往延迟。多药抗结核化疗仍然是儿童结核病治疗的主要方法。在某些情况下需要手术以获取组织、确保更好的关节活动、预防畸形并恢复神经功能。

结论

结核病可能有多种表现形式,因此在对任何感染性病变进行检查时,必须将结核感染列入鉴别诊断。在绝大多数情况下,保守治疗会产生良好效果。手术仅适用于特定指征。

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