Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, UK.
Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, UK.
J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):652-659. doi: 10.1093/gerona/glx223.
Sarcopenia has been associated with reduced physical activity (PA). We aimed to determine if sarcopenia, and specific components of muscle size, function, and physical performance, are associated with high impacts achieved during habitual PA, as these are related to bone strength in community-dwelling older women.
Participants were older women from the Cohort of Skeletal Health in Bristol and Avon. We defined sarcopenia using the EWGSOP criteria. Lower limb peak muscle power and force were assessed using Jumping Mechanography (JM). High vertical impacts were assessed by tri-axial accelerometry (at least 1.5g above gravity). Cross-sectional associations were analyzed by linear regression, adjusting for age, height and weight (or fat mass for models including appendicular lean mass index), comorbidities, smoking, alcohol, and Index of Multiple Deprivation.
Our analyses included 380 participants, with mean age 76.7 (SD 3.0) years; 242 (64%) also completed JM. In age-adjusted analysis, a negative relationship was observed between severity of sarcopenia and high, but not medium or low, impacts (p = .03 for trend). Regarding components of sarcopenia underlying this relationship, multivariable analyses revealed that gait speed (β 1.47 [95% CI 1.14, 1.89], [β-1] reflects the proportionate increase in high impacts per SD increase in exposure) and peak force (1.40 [1.07, 1.84]) were independently associated with high impacts.
Older women with sarcopenia experienced fewer bone-strengthening high impacts than those with presarcopenia or without sarcopenia. To increase bone strengthening activity in older women, interventions need to improve both lower limb muscle force and walking speed.
肌少症与体力活动（PA）减少有关。我们旨在确定肌少症以及肌肉大小、功能和身体表现的特定成分是否与习惯性 PA 期间达到的高冲击力有关，因为这些与社区居住的老年女性的骨强度有关。
参与者来自布里斯托尔和雅芳的骨骼健康队列。我们使用 EWGSOP 标准定义肌少症。使用跳跃力学（JM）评估下肢峰值肌肉力量和力量。通过三轴加速度计（高于重力至少 1.5g）评估高垂直冲击力。通过线性回归分析横断面关联，调整年龄、身高和体重（或包括四肢瘦体重指数的模型中的脂肪质量）、合并症、吸烟、酒精和多重剥夺指数。
我们的分析包括 380 名参与者，平均年龄 76.7（SD 3.0）岁；242 名（64%）还完成了 JM。在年龄调整分析中，肌少症严重程度与高但非中或低冲击力之间观察到负相关（趋势 p =.03）。关于这种关系的肌少症基础成分，多变量分析显示，步态速度（β 1.47 [95% CI 1.14, 1.89]，[β-1] 反映了每增加一个标准差暴露，高冲击力的比例增加）和峰值力（1.40 [1.07, 1.84]）与高冲击力独立相关。
与无肌少症或肌少前症的女性相比，肌少症女性经历的骨强化高冲击力较少。为了增加老年女性的骨强化活动，干预措施需要改善下肢肌肉力量和步行速度。
