McCullough Marjorie L, Jacobs Eric J, Shah Roma, Campbell Peter T, Wang Ying, Hartman Terryl J, Gapstur Susan M
Epidemiology Research Program, American Cancer Society, 250 Williams St. NE, Atlanta, GA, 30303-1002, USA.
Department of Epidemiology, Rollins School of Public Health, Winship Cancer Institute, Emory University, Atlanta, GA, USA.
Cancer Causes Control. 2018 Jan;29(1):125-133. doi: 10.1007/s10552-017-0984-x. Epub 2017 Nov 28.
Prospective cohort studies suggest that red and processed meat consumption is associated with increased risk of pancreatic cancer among men, but not women. However, evidence is limited, and less evidence exists for other types of meat.
Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios (HR) for the association of meat consumption, by type, with pancreatic cancer risk among 138,266 men and women in the Cancer Prevention Study-II Nutrition Cohort. Diet was assessed at baseline in 1992, and 10 years earlier, at enrollment into the parent CPS-II mortality cohort. 1,156 pancreatic cancers were verified through 2013.
Red meat, processed meat, and fish intake at baseline were not associated with pancreatic cancer risk. However, for long-term red and processed meat consumption (highest quartiles in 1982 and 1992, vs. lowest quartiles), risk appeared different in men [hazard ratio (HR) 1.32, 95% confidence interval (CI) 0.90, 1.95] and women (HR 0.72, 95% CI 0.47, 1.10, p heterogeneity by sex = 0.05). Poultry consumption in 1992 was associated with increased pancreatic cancer risk (HR 1.27, 95% CI 1.04, 1.55, p trend = 0.01, top vs. bottom quintile).
The associations of meat consumption with pancreatic cancer risk remain unclear and further research, particularly of long-term intake, is warranted.
前瞻性队列研究表明，男性食用红肉和加工肉类与胰腺癌风险增加有关，但女性并非如此。然而，证据有限，其他类型肉类的证据更少。
采用Cox比例风险回归模型，估计癌症预防研究-II营养队列中138,266名男性和女性按肉类类型划分的肉类消费与胰腺癌风险之间的多变量调整风险比（HR）。1992年在基线时评估饮食情况，10年前在加入CPS-II死亡率队列时评估。截至2013年共确诊1156例胰腺癌。
基线时红肉、加工肉类和鱼类摄入量与胰腺癌风险无关。然而，对于长期红肉和加工肉类消费（1982年和1992年最高四分位数与最低四分位数相比），男性风险似乎有所不同[风险比（HR）1.32，95%置信区间（CI）0.90，1.95]，女性风险为（HR 0.72，95%CI 0.47，1.10，性别异质性p = 0.05）。1992年食用家禽与胰腺癌风险增加有关（HR 1.27，95%CI 1.04，1.55，p趋势 = 0.01，最高五分位数与最低五分位数相比）。
肉类消费与胰腺癌风险之间的关联仍不明确，需要进一步研究，尤其是长期摄入量方面。
