Larsson Susanna C, Håkanson Niclas, Permert Johan, Wolk Alicja
Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Int J Cancer. 2006 Jun 1;118(11):2866-70. doi: 10.1002/ijc.21732.
High meat consumption has been associated with increased risk of pancreatic cancer in several, although not all, case-control studies. However, prospective data on this relationship are sparse, and the results have been inconsistent. We prospectively evaluated meat, fish, poultry, and egg consumption in relation to pancreatic cancer incidence in a population-based cohort of 61,433 Swedish women. Diet was assessed with a food-frequency questionnaire at baseline (1987-1990) and again in 1997. Pancreatic cancers were ascertained through linkage to the Swedish Cancer Register. Cox proportional hazards models were used to estimate multivariate hazard ratios with 95% confidence intervals (CI). During the 941,218 person-years of follow-up, from 1987 through 2004, 172 incident cases of pancreatic cancer were diagnosed. Long-term red meat consumption (using data from both dietary questionnaires) was positively associated with risk of pancreatic cancer (p-trend = 0.01), whereas long-term poultry consumption was inversely (p-trend = 0.04) associated with risk. The multivariate hazard ratios for the highest versus the lowest category of consumption were 1.73 (95% CI = 0.99-2.98) for red meat and 0.44 (95% CI = 0.20-0.97) for poultry. There were no significant associations with processed meat, fish or egg consumption. Findings from this prospective study suggest that substituting poultry for red meat might reduce the risk of pancreatic cancer.
在一些（尽管并非所有）病例对照研究中，高肉类摄入量与胰腺癌风险增加有关。然而，关于这种关系的前瞻性数据很少，且结果并不一致。我们对瑞典61433名女性的人群队列中肉类、鱼类、家禽和蛋类的摄入量与胰腺癌发病率之间的关系进行了前瞻性评估。在基线时（1987 - 1990年）以及1997年再次使用食物频率问卷评估饮食情况。通过与瑞典癌症登记处的关联确定胰腺癌病例。使用Cox比例风险模型估计多变量风险比及95%置信区间（CI）。在1987年至2004年的941218人年随访期间，共诊断出172例胰腺癌新发病例。长期红肉摄入量（使用两份饮食问卷的数据）与胰腺癌风险呈正相关（p趋势 = 0.01），而长期家禽摄入量与风险呈负相关（p趋势 = 0.04）。最高摄入量组与最低摄入量组相比，红肉的多变量风险比为1.73（95% CI = 0.99 - 2.98），家禽为0.44（95% CI = 0.20 - 0.97）。加工肉类、鱼类或蛋类摄入量与胰腺癌无显著关联。这项前瞻性研究的结果表明，用家禽替代红肉可能会降低胰腺癌风险。
