Somers K D, Sismour E N, Wright G L, Devine C J, Gilbert D A, Horton C E
Microbiology/Immunology Dept., Eastern Virginia Medical School, Norfolk 23501.
J Urol. 1989 Mar;141(3):629-31. doi: 10.1016/s0022-5347(17)40920-7.
Peyronie's disease is characterized histologically by excessive collagen deposition in the lesion. We examined the collagen types in Peyronie's disease plaque tissues compared to unaffected tissues from the same patient, other control tissues, and Dupuytren's contracture. Gel electrophoresis of pepsin-solubilized collagen demonstrated the presence of type I collagen and an increased content of type III collagen in plaque tissue. Increased type III collagen was detected in apparently normal tissue adjacent to the plaque and in Dupuytren's lesion, confirming previous findings. Although the cause of excessive collagen accumulation of Peyronie's disease is unknown, the results suggest an imbalance in the regulation of extracellular matrix production leading to pathologic fibrosis.
佩罗尼氏病在组织学上的特征是病变部位胶原蛋白过度沉积。我们将佩罗尼氏病斑块组织中的胶原类型与同一患者的未受影响组织、其他对照组织以及掌腱膜挛缩症组织进行了比较。对胃蛋白酶可溶解的胶原蛋白进行凝胶电泳显示，斑块组织中存在I型胶原蛋白，且III型胶原蛋白含量增加。在斑块附近看似正常的组织以及掌腱膜挛缩症病变组织中也检测到III型胶原蛋白增加，这证实了先前的研究结果。尽管佩罗尼氏病胶原蛋白过度积累的原因尚不清楚，但结果表明细胞外基质产生的调节失衡导致了病理性纤维化。
