Department of Biochemistry, Genetics and Immunology, Address Facultad de Biologia, University of Vigo, Vigo, Spain.
Bioinformatics. 2018 Mar 15;34(6):1043-1045. doi: 10.1093/bioinformatics/btx746.
There are many multiple testing correction methods. Some of them are robust to various dependencies in the data while others are not. Some of the implementations have problems for managing high dimensional list of P-values as currently demanded by microarray and other omic technologies.
The program Myriads, formerly SGoF+, provides some of the most important P-value-based correction methods jointly with a test of dependency and a P-value simulator. Myriads easily manage hundreds of thousands of P-values.
Supplementary data are available at Bioinformatics online.
有许多多重检验校正方法。其中一些方法对数据中的各种依赖关系具有稳健性,而另一些则不然。有些实现方法在管理目前微阵列和其他组学技术所要求的高维 P 值列表方面存在问题。
程序 Myriads(以前称为 SGoF+)提供了一些最重要的基于 P 值的校正方法,同时还提供了依赖性检验和 P 值模拟器。Myriads 可以轻松管理数十万 P 值。
补充数据可在 Bioinformatics 在线获得。