Department of Psychiatry & Neurobehavioural Science, University College Cork, Acute Mental Health Unit, Cork University Hospital, Wilton, Cork, Ireland.
South Lee Mental Health Service, Acute Mental Health Unit, Cork University Hospital, Wilton, Cork, Ireland.
Future Oncol. 2017 Dec;13(29):2719-2731. doi: 10.2217/fon-2017-0306. Epub 2017 Nov 30.
Corticosteroids are a central part of many cancer treatment regimens. Neuropsychiatric toxicity has complicated their use, including an association with a spectrum of symptoms, from insomnia, cognitive impairment and mood symptoms, to severe mental disorders, including mania, psychosis and severe depression. Although steroid-induced mental disorders were first reported in medicine more than 60 years ago, there is a dearth of evidence available to date on optimal treatment and prevention to guide cancer clinicians. We completed a systematic review of the current evidence for therapeutic and prophylactic interventions of steroid-induced mental disorders in cancer. We searched Medline, Embase and PsycINFO and selected studies related to steroid-induced mental disorder. The studies found were limited to case series and case reports only.
皮质类固醇是许多癌症治疗方案的重要组成部分。神经精神毒性使皮质类固醇的应用变得复杂，皮质类固醇与一系列症状相关，包括失眠、认知障碍和情绪症状，甚至严重的精神障碍，包括躁狂、精神病和严重抑郁。尽管皮质类固醇引起的精神障碍在 60 多年前的医学文献中就有报道，但迄今为止，关于最佳治疗和预防方法的证据很少，无法为癌症临床医生提供指导。我们对癌症中皮质类固醇引起的精神障碍的治疗和预防干预的现有证据进行了系统评价。我们检索了 Medline、Embase 和 PsycINFO，并选择了与皮质类固醇引起的精神障碍相关的研究。研究发现仅限于病例系列和病例报告。
