18F-氟代脱氧葡萄糖正电子发射断层扫描引导下的头颈部癌放疗计划制定与重新计划（自适应）：当前技术现状
F-Fdg-PET-guided Planning and Re-Planning (Adaptive) Radiotherapy in Head and Neck Cancer: Current State of Art.
作者信息
Farina Eleonora, Ferioli Martina, Castellucci Paolo, Farina Arianna, Zanirato Rambaldi Giuseppe, Cilla Savino, Cammelli Silvia, Fanti Stefano, Morganti Alessio G
机构信息
Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
出版信息
Anticancer Res. 2017 Dec;37(12):6523-6532. doi: 10.21873/anticanres.12108.
BACKGROUND/AIM: A review of the literature is proposed as a contribution to current knowledge on technical, physical, and clinical issues about PET-guided planning and re-planning radiotherapy (RT) in head and neck cancer.
MATERIALS AND METHODS
PubMed and Scopus electronic databases were searched for articles including clinical trials. Search terms were "gross tumor volume (GTV) delineation", "head and neck cancer", "radiotherapy", "adaptive radiotherapy" in combination with "PET".
RESULTS
A F-FDG-PET and CT-scan comparison in GTV definition for RT planning of head and neck cancer was shown in twenty-seven clinical trials with a total of 712 patients. Only two clinical trials focused on PET-guided adaptive radiotherapy (ART) with a total of 31 patients.
CONCLUSION
F-FDG-PET is able to achieve an accurate and precise definition of GTV boundaries during RT planning, especially in combination with CT-scan. ART strategies are proposed to evaluate tumor volume changes, plan boost irradiation on metabolically active residual neoplasm and protect organs at risk (OaRs).
背景/目的：对文献进行综述，以促进当前对头颈部癌正电子发射断层扫描（PET）引导下放疗计划制定及重新计划放疗的技术、物理和临床问题的认识。
材料与方法
在PubMed和Scopus电子数据库中检索包含临床试验的文章。检索词为“大体肿瘤体积（GTV）勾画”“头颈部癌”“放射治疗”“自适应放疗”并与“PET”组合。
结果
27项临床试验共纳入712例患者，展示了18F-FDG-PET与CT扫描在头颈部癌放疗计划GTV定义中的比较。仅有2项临床试验聚焦于PET引导下的自适应放疗（ART），共纳入31例患者。
结论
18F-FDG-PET能够在放疗计划期间准确且精确地定义GTV边界，尤其是与CT扫描相结合时。提出ART策略以评估肿瘤体积变化、计划对代谢活跃的残留肿瘤进行追加照射并保护危及器官（OaRs）。
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