Spartalis Eleftherios, Tsilimigras Diamantis I, Charalampoudis Petros, Karachaliou Georgia-Sofia, Moris Demetrios, Athanasiou Antonios, Spartalis Michael, Bolkas Vasileios, Dimitroulis Dimitrios, Nikiteas Nikolaos
Laboratory of Experimental Surgery and Surgical Research, University of Athens Medical School, Athens, Greece
Second Department of Propaedeutic Surgery, Laiko General Hospital, University of Athens Medical School, Athens, Greece.
Anticancer Res. 2017 Dec;37(12):6557-6562. doi: 10.21873/anticanres.12112.
Surgery remains the mainstay of treatment for breast cancer, including complete or partial mastectomy and lumpectomy. Breast reconstruction has gained popularity mainly due to its tremendous impact on the psychological status of the patients. Autologous fat grafting is a well-established method used in cosmetic surgery; however, fat re-absoprtion, fat necrosis, calcifications and oil-cyst formation are some usually encountered complications limiting the efficacy of this approach. Platelet-rich plasma (PRP) has recently been postulated as a promising method for tissue regeneration since it contains high levels of diverse human growth factors. To date, preliminary results from clinical studies regarding the combination of PRP and fat grafting in breast reconstruction have shown ambiguous results, whereas preclinical studies are more favorable. However, concerns have been raised regarding the extent of cellular promotion induced by PRP application and the corresponding potential malignant transformation. The aim of our study was to present, analyze and critically evaluate the role of PRP in breast reconstruction after breast cancer surgery in terms of efficacy and oncological safety highlighting the caution that needs to be taken in order to eliminate any chance of recurrence in patients who have theoretically undergone complete excision of the tumor burden.
手术仍然是乳腺癌治疗的主要手段，包括全乳切除术或部分乳房切除术以及肿块切除术。乳房重建越来越受欢迎，主要是因为它对患者心理状态有巨大影响。自体脂肪移植是整形外科中一种成熟的方法；然而，脂肪再吸收、脂肪坏死、钙化和油囊肿形成是一些常见的并发症，限制了这种方法的效果。富血小板血浆（PRP）最近被认为是一种有前景的组织再生方法，因为它含有高水平的多种人类生长因子。迄今为止，关于PRP与脂肪移植联合用于乳房重建的临床研究初步结果尚不明确，而临床前研究结果则更为乐观。然而，人们对PRP应用所诱导的细胞增殖程度以及相应的潜在恶性转化表示担忧。我们研究的目的是从疗效和肿瘤学安全性方面，对PRP在乳腺癌手术后乳房重建中的作用进行呈现、分析和批判性评估，强调需要谨慎行事，以消除理论上已完全切除肿瘤负荷的患者复发的任何可能性。
