Syllaios Athanasios, Tsimpoukelis Antonios, Vagios Ilias, Kyros Eleandros, Davakis Spyridon
First Department of Surgery, Laiko General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
J BUON. 2019 Jul-Aug;24(4):1516-1520.
The use of autologous fat transplantation for reconstruction purposes after mastectomy or Breast Conserving Treatment (BCT) for Breast Cancer (BC) has increased significantly the past twenty years. Adipose-derived stemm cells hold great tissue regenerative potential due to their established ability to improve the healing process through in situ differentiation and secretion of paracrine factors. Platelet-rich Plasma (PRP), contains high levels of diverse human growth factors for stem cells proliferation and differentiation in the course of tissue regeneration, and it has recently been accepted by many as a highly promising method for tissue regeneration. The molecular mechanisms mediating this effect are unclear and still remain under investigation. Major disadvantages on the use of PRP are not reported. Promising results in enhancing the survival of grafted fat has been shown with PRP with the potential of affecting patient's oncological outcome when applied on tumor excision sites.
在过去二十年中，自体脂肪移植用于乳腺癌（BC）乳房切除术后或保乳治疗（BCT）后的重建目的显著增加。脂肪来源干细胞具有巨大的组织再生潜力，因为它们具有通过原位分化和旁分泌因子分泌来改善愈合过程的既定能力。富含血小板血浆（PRP）含有高水平的多种人类生长因子，可在组织再生过程中促进干细胞增殖和分化，最近它已被许多人接受为一种极具前景的组织再生方法。介导这种效应的分子机制尚不清楚，仍在研究中。未报告使用PRP的主要缺点。已显示PRP在提高移植脂肪存活率方面有良好结果，当应用于肿瘤切除部位时可能会影响患者的肿瘤学结局。
