Luzo Angela C M, Fávaro Wagner J, Seabra Amedea B, Durán Nelson
Transfusion Medicine Service, Stem Cell Processing Laboratory, Umbilical Cord Blood Bank, Haematology Hemotherapy Center,University of Campinas (UNICAMP), Campinas, Brazil.
Laboratory of Urogenital Carcinogenesis and Immunotherapy, Department of Structural and Functional Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Heliyon. 2020 Mar 28;6(3):e03660. doi: 10.1016/j.heliyon.2020.e03660. eCollection 2020 Mar.
Platelet-rich-plasma (PRP) is an autologous human platelet concentrate extracted from plasma. PRP has been investigated in order to be used in many fields, with emphasis on the musculoskeletal field applied to sports injuries, as well as on other medical fields such as cardiac surgery, gynecology, pediatric surgery, urology, ophthalmology and plastic surgery. Cancer treatment is another important field where PRP should be investigated; thus, it is important validating PRP preparation protocols to be used in clinical research. Many protocols should be revised since, overall, most studies do not provide necessary information to allow them to be multiplied or replicated. The current review focuses on several topics about cancer, mainly on innovative studies about PRP use as a feasible therapeutic alternative to treat bladder cancer - a field where it could play a key role. Relevant aspects such as platelets' contribution to immune regulation and the supportive role they play in innate and adaptive immune functions are also addressed. Another important topic reviewed in the current study refers to inflammatory process regulation associated with cancer and thrombosis sites, which indicated that tumor-induced platelet activation could be used as an important therapeutic target in the future. New aspects concerning nitric oxide's ability to restrain platelet adhesion and aggregation in order to slow metastasis progress in cancer patients provide an important advantage in cancer treatment. Finally, the current review has pointed out perspectives and the main concerns about, and possibilities of, PRP use in cancer treatment.
富血小板血浆（PRP）是一种从血浆中提取的自体人血小板浓缩物。人们对PRP进行了研究，以便将其应用于许多领域，重点是应用于运动损伤的肌肉骨骼领域，以及心脏外科、妇科、小儿外科、泌尿外科、眼科和整形外科等其他医学领域。癌症治疗是另一个应研究PRP的重要领域；因此，验证用于临床研究的PRP制备方案很重要。许多方案都应修订，因为总体而言，大多数研究并未提供使其能够被重复或复制的必要信息。当前的综述聚焦于几个关于癌症的主题，主要是关于PRP作为治疗膀胱癌的可行治疗选择的创新性研究——在该领域PRP可能发挥关键作用。血小板对免疫调节的贡献以及它们在固有免疫和适应性免疫功能中所起的支持作用等相关方面也在文中有所探讨。当前研究中回顾的另一个重要主题涉及与癌症和血栓形成部位相关的炎症过程调节，这表明肿瘤诱导的血小板活化未来可能成为一个重要的治疗靶点。一氧化氮抑制血小板黏附和聚集以减缓癌症患者转移进程的新特性为癌症治疗提供了一个重要优势。最后，当前的综述指出了PRP在癌症治疗中的应用前景、主要关注点及可能性。
