Koensgen Dominique, Besic Ilma, Gümbel Denis, Kaul Anne, Weiss Martin, Diesing Karoline, Kramer Axel, Bekeschus Sander, Mustea Alexander, Stope Matthias B
Department of Gynecology and Obstetrics, University Medicine Greifswald, Greifswald, Germany.
Department of Trauma and Orthopaedic Surgery, University Medicine Greifswald, Greifswald, Germany.
Anticancer Res. 2017 Dec;37(12):6739-6744. doi: 10.21873/anticanres.12133.
BACKGROUND/AIM: Ovarian cancer (OC) is a gynecologic tumor with poor prognosis. Despite radical cytoreductive surgery and platinum-based adjuvant systemic treatment, OC will relapse in the majority of the cases. Thus, cold atmospheric plasma (CAP), a highly reactive physical state bearing diverse biological activities being suited for anticancer therapy, may be a promising option in OC therapy.
OC cell lines were exposed either directly to the CAP or to cell culture medium previously exposed to CAP. Cell proliferation and cell motility was measured.
The data demonstrated, that even a single application of a short-term CAP treatment led to an attenuation of OC cell growth and motility. Moreover, incubation with CAP-treated cell culture medium gave similar effects. Results were consistent in four OC cell lines.
In summary, the CAP application in oncological surgery leads to strong anti-proliferative effects and opens up novel opportunities for the OC treatment.
背景/目的：卵巢癌（OC）是一种预后较差的妇科肿瘤。尽管进行了根治性细胞减灭术和铂类辅助全身治疗，但大多数OC病例仍会复发。因此，冷大气等离子体（CAP）作为一种具有多种生物活性的高反应性物理状态，适合用于抗癌治疗，可能是OC治疗中一个有前景的选择。
将OC细胞系直接暴露于CAP或暴露于先前已暴露于CAP的细胞培养基中。测量细胞增殖和细胞运动能力。
数据表明，即使单次短期应用CAP治疗也会导致OC细胞生长和运动能力减弱。此外，用CAP处理过的细胞培养基孵育也产生了类似的效果。在四种OC细胞系中结果一致。
总之，在肿瘤外科手术中应用CAP可产生强大的抗增殖作用，并为OC治疗开辟了新的机会。
