碳离子放疗治疗不可切除性软骨肉瘤的临床疗效
Clinical Efficacy of Carbon Ion Radiotherapy for Unresectable Chondrosarcomas.
作者信息
Imai Reiko, Kamada Tadashi, Araki Nobuhito
机构信息
Hospital of the National Institute of Radiological Sciences, Quantum and Radiological Science and Technology, Chiba, Japan
Hospital of the National Institute of Radiological Sciences, Quantum and Radiological Science and Technology, Chiba, Japan.
出版信息
Anticancer Res. 2017 Dec;37(12):6959-6964. doi: 10.21873/anticanres.12162.
BACKGROUND
Carbon ion radiotherapy has precise dose distribution and high biological effectiveness and is likely a promising therapy for patients with sarcomas. We evaluated the outcomes of carbon ion radiotherapy in patients with unresectable chondrosarcomas.
PATIENTS AND METHODS
A retrospective analysis of 75 tumors in 73 patients treated with carbon ion radiotherapy was performed. There were 26 spinal, 38 pelvic, and 11 other types of tumors. Seventy conventional and five dedifferentiated chondrosarcomas were treated in 69 and four patients, respectively.
RESULTS
The median follow-up period was 49.4 (range=6.4-146.4) months. The 5-year local control, overall survival, and disease-free survival rates were 53%, 53%, and 34%, respectively. By multivariate analysis, tumor volume and histological grade were significantly related to overall and disease-free survival. Five patients required surgical intervention because of adverse events in the bones.
CONCLUSION
Carbon ion radiotherapy might be a treatment option for unresectable chondrosarcoma.
背景
碳离子放射治疗具有精确的剂量分布和高生物学效应，可能是肉瘤患者一种有前景的治疗方法。我们评估了碳离子放射治疗不可切除软骨肉瘤患者的疗效。
患者与方法
对73例接受碳离子放射治疗的患者的75个肿瘤进行回顾性分析。其中有26个脊柱肿瘤、38个骨盆肿瘤和11个其他类型的肿瘤。69例和4例患者分别接受了70例常规软骨肉瘤和5例去分化软骨肉瘤的治疗。
结果
中位随访期为49.4（范围=6.4-146.4）个月。5年局部控制率、总生存率和无病生存率分别为53%、53%和34%。多因素分析显示，肿瘤体积和组织学分级与总生存和无病生存显著相关。5例患者因骨骼不良事件需要手术干预。
结论
碳离子放射治疗可能是不可切除软骨肉瘤的一种治疗选择。
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