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南美洲主要变异表面抗原基因的进化结构：对流行传播和监测的影响。

Evolutionary structure of major variant surface antigen genes in South America: Implications for epidemic transmission and surveillance.

作者信息

Rougeron Virginie, Tiedje Kathryn E, Chen Donald S, Rask Thomas S, Gamboa Dionicia, Maestre Amanda, Musset Lise, Legrand Eric, Noya Oscar, Yalcindag Erhan, Renaud François, Prugnolle Franck, Day Karen P

机构信息

Department of Microbiology Division of Parasitology New York University School of Medicine New York NY USA.

MIVEGEC (Laboratoire Maladies Infectieuses et Vecteurs, Ecologie, Génétique, Evolution et Contrôle), UMR CNRS 5290/IRD 224 Université Montpellier 1 Université Montpellier 2 Montpellier France.

出版信息

Ecol Evol. 2017 Oct 8;7(22):9376-9390. doi: 10.1002/ece3.3425. eCollection 2017 Nov.

DOI:10.1002/ece3.3425
PMID:29187975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5696401/
Abstract

Strong founder effects resulting from human migration out of Africa have led to geographic variation in single nucleotide polymorphisms (SNPs) and microsatellites (MS) of the malaria parasite, . This is particularly striking in South America where two major founder populations of have been identified that are presumed to have arisen from the transatlantic slave trade. Given the importance of the major variant surface antigen of the blood stages of as both a virulence factor and target of immunity, we decided to investigate the population genetics of the genes encoding " Erythrocyte Membrane Protein 1" ( EMP1) among several countries in South America, in order to evaluate the transmission patterns of malaria in this continent. Deep sequencing of the DBLα domain of genes from 128 isolates from five locations in South America was completed using a 454 high throughput sequencing protocol. Striking geographic variation in DBLα sequences, similar to that seen for SNPs and MS markers, was observed. Colombia and French Guiana had distinct DBLα sequences, whereas Peru and Venezuela showed an admixture. The importance of such geographic variation to herd immunity and malaria vaccination is discussed.

摘要

人类从非洲迁出所导致的强烈奠基者效应，致使疟原虫的单核苷酸多态性（SNP）和微卫星（MS）出现地理变异。这在南美洲尤为显著，在那里已确定了疟原虫的两个主要奠基者群体，据推测它们源自跨大西洋奴隶贸易。鉴于疟原虫血液阶段主要变异表面抗原作为毒力因子和免疫靶点的重要性，我们决定研究南美洲几个国家中编码“红细胞膜蛋白1”（EMP1）的基因的群体遗传学，以便评估该大陆疟疾的传播模式。使用454高通量测序方案，完成了对来自南美洲五个地点的128株疟原虫分离株的基因DBLα结构域的深度测序。观察到DBLα序列存在显著的地理变异，类似于在SNP和MS标记中所见。哥伦比亚和法属圭亚那有不同的DBLα序列，而秘鲁和委内瑞拉则呈现混合情况。讨论了这种地理变异对群体免疫和疟疾疫苗接种的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c67/5696401/586f695ad6d2/ECE3-7-9376-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c67/5696401/72bedb52e65a/ECE3-7-9376-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c67/5696401/bb70f2b65473/ECE3-7-9376-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c67/5696401/5062c7245c4a/ECE3-7-9376-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c67/5696401/b1aafaaa50de/ECE3-7-9376-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c67/5696401/2606ea3c1470/ECE3-7-9376-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c67/5696401/586f695ad6d2/ECE3-7-9376-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c67/5696401/72bedb52e65a/ECE3-7-9376-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c67/5696401/bb70f2b65473/ECE3-7-9376-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c67/5696401/5062c7245c4a/ECE3-7-9376-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c67/5696401/b1aafaaa50de/ECE3-7-9376-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c67/5696401/2606ea3c1470/ECE3-7-9376-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c67/5696401/586f695ad6d2/ECE3-7-9376-g006.jpg

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