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[使用甲硝唑的癌症患者在放射治疗期间的止血作用]

[Hemostasis in cancer patients during radiation therapy using metronidazole].

作者信息

Chekalina S I, Berdov B A, Pavlov V V, Andreev V G

出版信息

Med Radiol (Mosk). 1989 Feb;34(2):52-6.

PMID:2918830
Abstract

Indices of platelet function, plasmic coagulation and fibrinolysis were studied during gamma-beam therapy in patients with laryngeal, gastric and cervical tumors (potentially at risk for thrombosis) against a background of metronidazole administration. During the above therapy the thrombophilic status of gastric cancer patients was preserved. These patients were considered at risk for thrombosis. In patients with laryngeal and cervical cancer platelet capacity to adhesion was considerably reduced during radiotherapy with the use of metronidazole. As a result of it the thrombogenic blood potential and danger of intravascular thrombogenesis were decreased.

摘要

在喉癌、胃癌和宫颈癌(有潜在血栓形成风险)患者接受伽马射线治疗期间,在使用甲硝唑的背景下,对血小板功能、血浆凝血和纤维蛋白溶解指标进行了研究。在上述治疗期间,胃癌患者的血栓形成倾向状态得以维持。这些患者被认为有血栓形成风险。在使用甲硝唑进行放射治疗期间,喉癌和宫颈癌患者的血小板黏附能力显著降低。因此,血栓形成性血液潜能和血管内血栓形成的风险降低。

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