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社区药房老年用药审查期间发现的药物相关问题。

Drug-related problems identified during geriatric medication review in the community pharmacy.

作者信息

Rhalimi Mounir, Rauss Alain, Housieaux Eric

机构信息

Centre Hospitalier Bertinot Juël, Service Pharmacie, 34 bis rue Pierre BUDIN, 60240, Chaumont en Vexin, France.

INSERM U1088, Université de Picardie Jules Verne, Amiens, France.

出版信息

Int J Clin Pharm. 2018 Feb;40(1):109-118. doi: 10.1007/s11096-017-0571-y. Epub 2017 Nov 29.

Abstract

Background In line with the changing role of community pharmacists, we describe here a standardised procedure for detecting DRPs in elderly patients for use in community pharmacies. Objectives The primary aim was to describe the number and type of DRPs identified by community pharmacists in elderly patients. Secondary aims were to determine the number and type of associated pharmacist interventions (PIs) that were transmitted to the prescribers, and to identify risk factors associated with the occurrence of a PI. Setting Community pharmacies. Methods In this prospective, multicentre study, pharmacists received patients aged 65 and over. During a 30-min interview with patients who agreed to participate, patient characteristics were recorded such as age, weight, height, frailty (using the Short Emergency Geriatric Assessment grid), estimated renal function and compliance with treatment assessed by the Girerd scale. Main outcome measure DRPs characteristics. Results A total of 892 patients agreed to participate in 55 pharmacies. Among them 334 DRPs were identified and were associated with 259 PIs. Eighty-nine PIs of 259 were sent to the prescribing physicians; 70 (78%) were implemented by the general practitioner. Factors associated with the occurrence of a DRP are compliance problems [odds ratio (OR) = 1.8, 95% confidence interval (CI) (1.26-2.58)], frailty [OR = 1.3, 95% CI (1.01-1.66)], number of prescribed drugs per day [OR = 1.46, 95% CI (1.02-2.07)] and GFR < 60 mL/min [OR = 1.49, 95% CI (1.01-2.2)]. Conclusion This is the first standardised pharmaceutical assessment dedicated to the elderly carried out by community pharmacists in France. If implemented, it could help to find drug-related problems, identify frail elderly patients and ultimately decrease their exposure to iatrogenic medication errors.

摘要

背景 随着社区药剂师角色的转变,我们在此描述一种用于社区药房检测老年患者药物相关问题(DRP)的标准化程序。目的 主要目的是描述社区药剂师在老年患者中识别出的DRP的数量和类型。次要目的是确定传递给开处方医生的相关药剂师干预措施(PI)的数量和类型,并识别与PI发生相关的风险因素。地点 社区药房。方法 在这项前瞻性多中心研究中,药剂师接待65岁及以上的患者。在与同意参与的患者进行30分钟访谈期间,记录患者特征,如年龄、体重、身高、虚弱程度(使用简易急诊老年评估量表)、估算肾功能以及通过吉尔德量表评估的治疗依从性。主要结局指标 DRP特征。结果 共有892名患者同意在55家药房参与研究。其中识别出334个DRP,与259次PI相关。259次PI中有89次发送给了开处方医生;70次(78%)由全科医生实施。与DRP发生相关的因素有依从性问题[比值比(OR)=1.8,95%置信区间(CI)(1.26 - 2.58)]、虚弱[OR = 1.3,95% CI(1.01 - 1.66)]、每日处方药数量[OR = 1.46,95% CI(1.02 - 2.07)]以及肾小球滤过率(GFR)<60 mL/min[OR = 1.49,95% CI(1.01 - 2.2)]。结论 这是法国社区药剂师首次针对老年人开展的标准化药学评估。如果实施,它有助于发现药物相关问题,识别虚弱老年患者,并最终减少他们暴露于医源性用药错误的风险。

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