Wang Weiping, Fan Weixing, Shi Bo, Tong Chunnan, Wang Xiaorong, Cai Jun, Zhang Chen
Jinhua Second Hospital, Jinhua, Zhejiang 321016, China. Email:
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017 Dec 10;34(6):905-908. doi: 10.3760/cma.j.issn.1003-9406.2017.06.028.
To investigate the effect of MTHFR gene on schizophrenia and its cognitive function.
We recruited 254 schizophrenia patients with stable condition, 339 healthy controls for genetic analysis and 72 healthy controls for cognitive evaluation. The repeatable battery for the assessment of neuropsychological status (RBANS) was used for cognitive measurement. PCR-RFLP technique was carried out to genotype 677C/T polymorphism.
There were no significant differences in genotypic or allelic frequencies of the 677C/T polymorphism between the case and control groups (P> 0.05). In the RBANS, patients had higher scores of immediate memory, visuospatial skill, language, attention, delayed memory and total scores than healthy controls (P< 0.01); Patients with different genotypes of 677C/T polymorphism had significant differences in the scores of immediate memory, attention and total scores (P< 0.05).
Our results did not provide evidence for MTHFR gene conferring susceptibility to schizophrenia. However, there was a significant association between the MTHFR gene and cognitive impairment in patients with schizophrenia, especially in immediate memory and attention.
探讨亚甲基四氢叶酸还原酶（MTHFR）基因对精神分裂症及其认知功能的影响。
我们招募了254例病情稳定的精神分裂症患者、339例用于基因分析的健康对照者以及72例用于认知评估的健康对照者。采用可重复成套神经心理状态评估量表（RBANS）进行认知测量。运用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术对677C/T多态性进行基因分型。
病例组与对照组之间677C/T多态性的基因型频率或等位基因频率无显著差异（P>0.05）。在RBANS量表中，患者在即刻记忆、视觉空间技能、语言、注意力、延迟记忆及总分方面的得分高于健康对照者（P<0.01）；677C/T多态性不同基因型的患者在即刻记忆、注意力及总分方面的得分存在显著差异（P<0.05）。
我们的研究结果未提供MTHFR基因赋予精神分裂症易感性的证据。然而，MTHFR基因与精神分裂症患者的认知损害之间存在显著关联，尤其是在即刻记忆和注意力方面。
