Biologically active compounds from the red sea sponge Suberea sp.

Investigation of the cytotoxic fraction of the extracts of the Red Sea sponge Suberea sp. resulted in the identification of two new compounds, 1-(hydroxy(1H-pyrrol-2-yl)methyl)guanidine and 4-(2-amino-3-methylbut-3-en-1-yl)phenol (1 and 2) together with the previously reported 2-(3,5-dibromo-4-hydroxyphenyl)acetamide (3), subereaphenol C (4), dibromoverongiaquinol (5) and bromochloroverongiaquinol (6). The compounds were assigned by assignment of their one- and two-dimensional NMR and MS spectral data. The cytotoxic activities of the compounds against two cancer cell lines were evaluated. In addition, the antimicrobial activities of the compounds was discussed.