Max Planck Institute for Chemical Ecology, Jena.
Chem Biodivers. 2010 Dec;7(12):2880-7. doi: 10.1002/cbdv.200900277.
Two new brominated compounds, subereaphenol K (2) and 2-(3,5-dibromo-1-ethoxy-4-oxocyclohexa-2,5-dien-1-yl)acetamide (3), together with subereaphenol B (methyl 2-(2,4-dibromo-3,6-dihydroxyphenyl)acetate; 1) with a revised structure, and five dibromotyrosine-derived metabolites, 4-8, were isolated from the sponge Suberea sp. and characterized by 1D- and 2D-NMR spectroscopic and HR-MS spectrometric data. Compounds 1, 2, 6, and 8 exhibited various weak or moderate bioactivities, including antimicrobial and cytotoxic activities. Furthermore, compounds 1 and 2 inhibited human recombinant phosphodiesterase 4 (PDE4) with IC₅₀ values of 2 μM, whereas compounds 6 and 8 were less active.
从海绵 Suberea sp. 中分离得到两个新的溴化化合物，即 subereaphenol K（2）和 2-(3,5-二溴-1-乙氧基-4-氧代环己烷-2,5-二烯-1-基)乙酰胺（3），以及 subereaphenol B（2-(2,4-二溴-3,6-二羟基苯基）乙酸甲酯；1），其结构经过修订，以及五个二溴酪氨酸衍生的代谢物，即 4-8。通过 1D-和 2D-NMR 光谱和 HR-MS 光谱数据对这些化合物进行了鉴定。化合物 1、2、6 和 8 表现出各种弱或中等的生物活性，包括抗菌和细胞毒性活性。此外，化合物 1 和 2 以 2 μM 的 IC₅₀ 值抑制人重组磷酸二酯酶 4（PDE4），而化合物 6 和 8 的活性较低。
