Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Univ. Paris-Sud, University of Paris-Saclay, 1, Avenue de la Terrasse, 91198 Gif-Sur-Yvette, France.
Organic Chemistry Division, Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt.
Mar Drugs. 2019 Feb 12;17(2):115. doi: 10.3390/md17020115.
Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 30,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a profound, renewable source to investigate novel drug compounds. Marine sponges of the genus (family: Aplysinellidae) are recognized as producers of bromotyrosine derivatives, which are considered distinct chemotaxonomic markers for the marine sponges belonging to the order Verongida. This class of compounds exhibits structural diversity, ranging from simple monomeric molecules to more complex molecular scaffolds, displaying a myriad of biological and pharmacological potentialities. In this review, a comprehensive literature survey covering the period of 1998⁻2018, focusing on the chemistry and biological/pharmacological activities of marine natural products from marine sponges of the genus , with special attention to the biogenesis of the different skeletons of halogenated compounds, is presented.
海洋天然产物（MNPs）在全球药物发现中仍然备受关注。目前，已经从海洋来源中分离出了超过 30000 种结构多样的次级代谢产物，使 MNPs 成为一个深远的、可再生的资源，可用于研究新型药物化合物。属于 Aplysinellidae 科的海绵属被认为是溴代酪氨酸衍生物的生产者，这些衍生物被认为是属于 Verongida 目海洋海绵的独特化学分类标记。这一类化合物表现出结构多样性，从简单的单体分子到更复杂的分子支架，显示出多种生物和药理学潜力。在这篇综述中，我们对 1998 年至 2018 年期间的文献进行了全面调查，重点介绍了海绵属海洋海绵的海洋天然产物的化学和生物/药理学活性，特别关注不同卤化化合物骨架的生物发生。
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