Institute of Organic Chemistry, University of Würzburg , Am Hubland, D-97074 Würzburg, Germany.
Faculté des Sciences, Université de Kinshasa , B.P. 202, Kinshasa XI, Democratic Republic of the Congo.
Org Lett. 2017 Dec 15;19(24):6740-6743. doi: 10.1021/acs.orglett.7b03473. Epub 2017 Nov 30.
From the leaves of a yet undescribed Congolese Ancistrocladus species, two novel naphthylisoquinoline dimers, spirombandakamines A (1) and A (2), were isolated, together with a new, but "classical" dimer, mbandakamine B (3). The cage-like stereostructures of 1 and 2 were established by combining spectroscopic, chemical, and chiroptical methods with quantum-chemical ECD calculations. Their unique molecular frameworks may originate from "open-chain" dimers, such as 3, by an oxidation-induced cascade of reactions. They possess strong antiprotozoal properties.
从一种尚未被描述的刚果Ancistrocladus 物种的叶子中，分离得到了两种新型的萘基异喹啉二聚体，螺旋邦达克胺 A（1）和 A（2），以及一种新的但“经典”的二聚体，邦达克胺 B（3）。通过结合光谱、化学和手性光学方法以及量子化学 ECD 计算，确定了 1 和 2 的笼状立体结构。它们独特的分子框架可能源自“开链”二聚体，如 3，通过氧化诱导的级联反应形成。它们具有很强的抗原生动物特性。
