在桔霉素生物合成过程中，CitA对载体蛋白结合的酰基中间体进行反式水解。
In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis.
作者信息
Storm Philip A, Townsend Craig A
机构信息
Department of Chemistry, Johns Hopkins University, 3400 N Charles St, Baltimore, MD 21218, USA.
出版信息
Chem Commun (Camb). 2017 Dec 19;54(1):50-53. doi: 10.1039/c7cc07079a.
Abstract
Polyketide synthases (PKSs) have several known editing mechanisms to ensure that non-productive intermediates are removed from the acyl carrier protein (ACP). We demonstrate that CitA, a putative hydrolase in the citrinin biosynthetic gene cluster, removes ACP-bound acyl intermediates. We propose that it serves an editing role in trans.
摘要
聚酮合酶（PKSs）有几种已知的编辑机制，以确保非生产性中间体从酰基载体蛋白（ACP）上被去除。我们证明，citrinin生物合成基因簇中的一种假定水解酶CitA可去除与ACP结合的酰基中间体。我们认为它在转位过程中起编辑作用。
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