Beesdo-Baum Katja, Knappe Susanne, Einsle Franziska, Knothe Lisa, Wieder Gesine, Venz John, Rummel-Kluge Christine, Heinz Ines, Koburger Nicole, Schouler-Ocak Meryam, Wilbertz Theresia, Unger Hans-Peter, Walter Ulrich, Hein Joachim, Hegerl Ulrich, Lieb Roselind, Pfennig Andrea, Schmitt Jochen, Hoyer Jürgen, Wittchen Hans-Ulrich, Bergmann Antje
Institut für Klinische Psychologie und Psychotherapie, Behaviorale Epidemiologie & Center for Clinical Epidemiology and Longitudinal Studies, Technische Universität Dresden, Chemnitzer Str. 46, 01187, Dresden, Deutschland.
Behaviorale Epidemiologie, Technische Universität Dresden, Dresden, Deutschland.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2018 Jan;61(1):52-64. doi: 10.1007/s00103-017-2662-2.
Primary care physicians (PCPs) play a crucial role for guideline-oriented intervention in patients with depression.
Based on a diagnostic screening questionnaire, this study investigates the sensitivity of PCPs to recognize patients with depression as well as the factors facilitating recognition and concordant diagnostic decisions.
In a cross-sectional epidemiological study in six regions of Germany, 3563 unselected patients filled in questionnaires on mental and physical complaints and were diagnostically evaluated by their PCP (N = 253). The patient reports on an established Depression-Screening-Questionnaire (DSQ), which allows the approximate derivation of an ICD-10 depression diagnosis, were compared with the physician diagnosis (N = 3211). In a subsample of discordant cases a comprehensive standardized clinical-diagnostic interview (DIA-X/CIDI) was applied.
On the study day, the prevalence of ICD-10 depression was 14.3% according to the DSQ and 10.7% according to the physician diagnosis. Half of the patients identified by DSQ were diagnosed with depression by their physician and two thirds were recognized as mental disorder cases. More severe depression symptomatology and the persistent presence of main depression symptoms were related to better recognition and concordant diagnostic decisions. Diagnostic validation interviews confirmed the DSQ diagnosis in the majority of the false-negative cases. Indications for at least a previous history of depression were found in up to 70% of false-positive cases.
Given the high prevalence of depression in primary care patients, there is continued need to improve the recognition and diagnosis of these patients to assure guideline-oriented treatment.
基层医疗医生(PCP)在对抑郁症患者进行以指南为导向的干预中起着关键作用。
基于一份诊断筛查问卷,本研究调查基层医疗医生识别抑郁症患者的敏感性,以及促进识别和一致诊断决策的因素。
在德国六个地区进行的一项横断面流行病学研究中,3563名未经筛选的患者填写了关于心理和身体不适的问卷,并由他们的基层医疗医生(N = 253)进行诊断评估。将患者在一份既定的抑郁症筛查问卷(DSQ)上的报告(该问卷可大致得出ICD - 10抑郁症诊断)与医生诊断(N = 3211)进行比较。在不一致病例的子样本中,采用了全面的标准化临床诊断访谈(DIA - X/CIDI)。
在研究当天,根据DSQ,ICD - 10抑郁症的患病率为14.3%,根据医生诊断为10.7%。DSQ识别出的患者中有一半被医生诊断为抑郁症,三分之二被识别为精神障碍病例。更严重的抑郁症状以及主要抑郁症状的持续存在与更好的识别和一致的诊断决策相关。诊断验证访谈在大多数假阴性病例中证实了DSQ诊断。在高达70%的假阳性病例中发现了至少有抑郁症既往史的迹象。
鉴于基层医疗患者中抑郁症的高患病率,持续需要改善对这些患者的识别和诊断,以确保进行以指南为导向的治疗。