a Department of Ophthalmology , Peking University First Hospital , Beijing , China.
b Renal Division, Department of Medicine , Peking University First Hospital , Beijing , China.
Ocul Immunol Inflamm. 2019;27(3):371-379. doi: 10.1080/09273948.2017.1394469. Epub 2017 Nov 30.
: To analyze the clinical features and long-term prognosis of uveitis in tubulointerstitial nephritis and uveitis (TINU) syndrome in a cohort of Chinese patients. : A total of 32 patients with TINU syndrome between 2000 - 2016 were analyzed retrospectively. : Mild anterior inflammation was observed in all cases. Ultra-wide-field fluorescence angiography (UWFA) was conducted on 13 patients, and peripheral vascular leakage was observed in 22/26 eyes (84.62%) compared with active anterior chamber inflammation in 13/26 eyes (50%). Three patients received increased corticosteroid dosage therapy on their first episode of uveitis guided by UWFA had stopped steroids without recurrence. : The uveitis in TINU syndrome was mild. Corticosteroids were efficient in most cases, but a slower tapering and long-term treatment were required. UWFA is sensitive in detecting the activity of uveitis and might be useful in monitoring disease progression. Complete withdrawal of medication was difficult to achieve in some cases.
分析中国患者群体中 tubulointerstitial nephritis 和 uveitis (TINU) 综合征的葡萄膜炎的临床特征和长期预后。
回顾性分析了 2000 年至 2016 年间的 32 例 TINU 综合征患者。
所有病例均观察到轻度前炎症。对 13 例患者进行了超广角荧光血管造影(UWFA)检查,与 13/26 只眼(50%)活跃的前房炎症相比,22/26 只眼(84.62%)观察到周边血管渗漏。3 例患者在首次出现葡萄膜炎时根据 UWFA 增加了皮质类固醇剂量治疗,在没有复发的情况下停止了类固醇治疗。
TINU 综合征的葡萄膜炎为轻度。皮质类固醇在大多数情况下有效,但需要较慢的减量和长期治疗。UWFA 对检测葡萄膜炎的活动性很敏感,可能有助于监测疾病进展。在某些情况下,很难完全停止用药。