Tekin Kemal, Erol Yasemin Ozdamar, Kurtulan Olcay, Baydar Dilek Ertoy
Department of Ophthalmology, Ercis State Hospital, Van, Turkey.
Department of Uveal Diseases, Ankara Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
Taiwan J Ophthalmol. 2020 Mar 4;10(1):66-70. doi: 10.4103/tjo.tjo_33_18. eCollection 2020 Jan-Mar.
The tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disorder that is probably underdiagnosed in clinical practice. Ocular involvement in TINU syndrome not only presents with the nongranulomatous anterior uveitis in 80% of patients but also manifests as intermediate, posterior, or panuveitis. This case report mentions an adult male patient who presented with granulomatous iridocyclitis with panuveitis and mild renal insufficiency. Workup for connective tissue and infectious diseases was negative for the patient. He was diagnosed with TINU syndrome based on the findings of renal biopsy. Both the uveitis and nephritis promptly responded well to steroid treatment, and there was no recurrence during the follow-up of 24 months.
肾小管间质性肾炎和葡萄膜炎（TINU）综合征是一种罕见疾病，在临床实践中可能未得到充分诊断。TINU综合征的眼部受累不仅在80%的患者中表现为非肉芽肿性前葡萄膜炎，还可表现为中间、后部或全葡萄膜炎。本病例报告提及一名成年男性患者，表现为肉芽肿性虹膜睫状体炎伴全葡萄膜炎和轻度肾功能不全。该患者结缔组织和感染性疾病的检查结果均为阴性。根据肾活检结果，他被诊断为TINU综合征。葡萄膜炎和肾炎对类固醇治疗均迅速产生良好反应，在24个月的随访期间无复发。
