COVID-2019 大流行期间的肾小管间质性肾炎和葡萄膜炎综合征的诊断和表现特征。
Diagnosis and Characteristics of Presentation of Tubulointerstitial Nephritis and Uveitis Syndrome During the COVID-2019 Pandemic.
机构信息
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
Department of Ophthalmology, University of British Columbia, Vancouver, British Columbia, Canada.
出版信息
Ocul Immunol Inflamm. 2024 Sep;32(7):1351-1358. doi: 10.1080/09273948.2023.2244077. Epub 2023 Sep 12.
PURPOSE
To compare the diagnosis and clinical features of tubulointerstitial nephritis and uveitis syndrome (TINU) before and during the COVID-19 pandemic.
METHODS
Retrospective chart review.
RESULTS
Before the COVID-19 pandemic (March 2017 to March 2019), 1/561 (0.18%) new patient was diagnosed with TINU. During the pandemic (March 2020 to March 2022), 15/581 (2.58%) new patients were diagnosed with TINU. We found a significant increase in TINU cases during the pandemic (P=0.0005). Various posterior segment findings were observed in 2/3 (66.7%) patients before the pandemic and 13/15 (86.7%) patients during the pandemic, including disc edema, chorioretinal scars, disc leakage, and peripheral vascular leakage.
CONCLUSION
This is the first study reporting an increased number of TINU during the COVID-19 pandemic. With most of the American population now exposed to COVID-19, a large multi-center epidemiological study would be helpful to investigate any association of COVID-19 disease or vaccination with TINU in recent years.
目的
比较 COVID-19 大流行前后间质性肾炎和葡萄膜炎综合征（TINU）的诊断和临床特征。
方法
回顾性病历审查。
结果
在 COVID-19 大流行之前（2017 年 3 月至 2019 年 3 月），561 例新患者中诊断出 1 例 TINU（0.18%）。在大流行期间（2020 年 3 月至 2022 年 3 月），581 例新患者中诊断出 15 例 TINU。我们发现大流行期间 TINU 病例显著增加（P=0.0005）。在大流行之前，3 例患者中的 2 例（66.7%）和大流行期间的 15 例患者中的 13 例（86.7%）观察到各种后节发现，包括视盘水肿、脉络膜视网膜瘢痕、视盘渗漏和周围血管渗漏。
结论
这是第一项报告 COVID-19 大流行期间 TINU 病例增加的研究。由于现在大多数美国人口都接触过 COVID-19，一项大型多中心的流行病学研究将有助于调查 COVID-19 疾病或疫苗接种与近年来 TINU 之间的任何关联。
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