Wales Jeremy, Gladiné Kilian, Van de Heyning Paul, Topsakal Vedat, von Unge Magnus, Dirckx Joris
Department of Otorhinolaryngology, Karolinska University Hospital, Stockholm, Sweden.
Laboratory of Biomedical Physics, University of Antwerp, Antwerp, Belgium.
Hear Res. 2018 Jan;357:46-53. doi: 10.1016/j.heares.2017.11.007. Epub 2017 Nov 20.
Ossicular fixation through otosclerosis, chronic otitis media and other pathologies, especially tympanosclerosis, are treated by surgery if hearing aids fail as an alternative. However, the best hearing outcome is often based on knowledge of the degree and location of the fixation. Objective methods to quantify the degree and position of the fixation are largely lacking. Laser vibrometry is a known method to detect ossicular fixation but clinical applicability remains limited. A new method, minimally invasive laser vibrometry (MIVIB), is presented to quantify ossicle mobility using laser vibrometry measurement through the ear canal after elevating the tympanic membrane, thus making the method feasible in minimally invasive explorative surgery. A floating mass transducer provides a clinically relevant transducer to drive ossicular vibration. This device was attached to the manubrium and drove vibrations at the same angle as the longitudinal axis of the stapes and was therefore used to assess ossicular chain mobility in a fresh-frozen temporal bone model with and without stapes fixation. The ratio between the umbo and incus long process was shown to be useful in assessing stapes fixation. The incus-to-umbo velocity ratio decreased by 15 dB when comparing the unfixated situation to stapes fixation up to 2.5 kHz. Such quantification of ossicular fixation using the incus-to-umbo velocity ratio would allow quick and objective analysis of ossicular chain fixations which will assist the surgeon in surgical planning and optimize hearing outcomes.
耳硬化症、慢性中耳炎及其他病变(尤其是鼓室硬化症)导致的听骨固定,如果助听器作为替代手段效果不佳,则通过手术治疗。然而,最佳听力结果往往取决于对固定程度和位置的了解。目前很大程度上缺乏量化固定程度和位置的客观方法。激光振动测量法是一种已知的检测听骨固定的方法,但临床适用性仍然有限。本文介绍了一种新方法——微创激光振动测量法(MIVIB),即在抬高鼓膜后通过耳道进行激光振动测量来量化听小骨的活动度,从而使该方法在微创探查手术中切实可行。一种浮动质量换能器提供了一种与临床相关的换能器来驱动听骨振动。该装置附着于锤骨柄,并以与镫骨纵轴相同的角度驱动振动,因此被用于评估新鲜冷冻颞骨模型中有无镫骨固定情况下的听骨链活动度。结果表明,鼓膜脐与砧骨长突之间的比率有助于评估镫骨固定情况。在比较未固定情况与镫骨固定情况时,在高达2.5kHz的频率下,砧骨至鼓膜脐的速度比降低了15dB。使用砧骨至鼓膜脐速度比来量化听骨固定,将有助于快速、客观地分析听骨链固定情况,协助外科医生进行手术规划并优化听力结果。