Marinho Eduarda da Costa, Custódio Isis Danyelle Dias, Ferreira Isabela Borges, Crispim Cibele Aparecida, Paiva Carlos Eduardo, Maia Yara Cristina de Paiva
Graduate Program in Health Sciences, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil.
Nutrition Course, Medical Faculty, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil.
PLoS One. 2017 Nov 30;12(11):e0187573. doi: 10.1371/journal.pone.0187573. eCollection 2017.
Breast cancer (BC) treatment includes mostly chemotherapy (CT), which can cause side effects like nausea, taste changes, early satiety, slow gastric emptying and xerostomia. In this way, the individual's relationship with food may change during the treatment. The aim of this study was to evaluate the impact of chemotherapy on perceptions related to food intake of women with BC. Fifty-five women with BC were followed, and data were collected at three periods during first-line CT: beginning (T0), intermediate (T1) and end (T2). A visual analogue scale (VAS) (0 to 10 cm) for hunger, appetite for various food categories and meal enjoyment was investigated. The frequency and intensity of side effects were evaluated using a 4 cm scale. The results showed a higher prevalence of taste changes in T1 (p = 0.044) and more nausea in T1 and T2 (p = 0.018). Furthermore, the intensity of nausea was higher in T2 (p = 0.01) than in the other periods. We observed moderate hunger in T0, T1 and T2 (p = 0.113), but the overall appetite increased between T0 and T2 (p = 0.003). Meal enjoyment was reduced from T0 to T1and returned back to the initial value in T2 (p = 0.021). The appetite for salty (p = 0.004) and spicy (p = 0.03) foods was increased in T1. There was an increase of body weight (p = 0.008), body mass index (BMI) (p = 0.009) and waist circumference (WC) (p = 0.03) during CT. CT changes food hedonism, increasing the overall appetite and the appetite for salty and spicy foods. Moreover, we observed the negative impact of CT on meal enjoyment and an increase in side effects and anthropometric parameters.
乳腺癌（BC）治疗主要包括化疗（CT），化疗会引发恶心、味觉改变、早饱、胃排空延迟和口干等副作用。如此一来，患者在治疗期间与食物的关系可能会发生变化。本研究旨在评估化疗对BC女性患者食物摄入相关认知的影响。对55名BC女性患者进行随访，并在一线化疗的三个阶段收集数据：开始阶段（T0）、中期（T1）和结束阶段（T2）。研究了用于评估饥饿感、各类食物食欲和用餐愉悦感的视觉模拟量表（VAS）（0至10厘米）。使用4厘米量表评估副作用的频率和强度。结果显示，T1期味觉改变的发生率更高（p = 0.044），T1期和T2期恶心症状更多（p = 0.018）。此外，T2期恶心的强度高于其他阶段（p = 0.01）。我们观察到T0、T1和T2期均有中度饥饿感（p = 0.113），但从T0到T2总体食欲有所增加（p = 0.003）。用餐愉悦感从T0到T1降低，并在T2期恢复到初始值（p = 0.021）。T1期对咸味（p = 0.004）和辣味（p = 0.03）食物的食欲增加。化疗期间体重（p = 0.008）、体重指数（BMI）（p = 0.009）和腰围（WC）（p = 0.03）均有所增加。化疗改变了食物享乐主义，增加了总体食欲以及对咸味和辣味食物的食欲。此外，我们观察到化疗对用餐愉悦感有负面影响，且副作用和人体测量参数增加。
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