Graduate Program in Health Sciences, Federal University of Uberlandia, Uberlandia, 38405-320 Minas Gerais, Brazil.
Nutrition Course, Medical Faculty, Federal University of Uberlandia, Uberlandia, 38405-320 Minas Gerais, Brazil.
Nutrients. 2019 Nov 1;11(11):2610. doi: 10.3390/nu11112610.
Considering the implications of adverse effects of chemotherapy (CT) and the potential impact of diet on patients' recovery, this study aimed to prospectively evaluate the association between the consumption of food groups, patients' Dietary Inflammatory Index (DII) scores, and their nutritional status. Anthropometric and dietary assessments of 55 women with breast cancer (BC) were performed at three time points. T0 is the time point after the first CT cycle, T1 is the time point after the intermediate CT cycle, and T2 is the time point after the last CT cycle. We identified a significant increase in weight, body mass index, and waist circumference during CT. Consumption of poultry and eggs was higher in T1 when compared to T2, while consumption of total fruit and total vegetables was higher at T0 compared to T1 and T2. The diet became more pro-inflammatory over the course of treatment (X = 61.127), and was related to higher abdominal adiposity. Total fruit (T0: R = 0.208, T1: R = 0.095, T2: R = 0.120) and total vegetable consumption (T0: R = 0.284, T1: R = 0.365, T2: R = 0.580) predicted DII change at the three-time points. Meanwhile, consumption of total grains was significantly associated only with T1 (R = 0.084) and T2 (R = 0.118), and consumption of simple sugars was significantly associated only with T0 (R = 0.137) and T1 (R = 0.126). Changes in food consumption led to an increase in the inflammatory profile of the diet, suggesting the necessity to improve the guidelines during and after CT. These results reinforce the need to promote healthier eating practices in concert with maintaining a healthy nutritional status in women with BC treated with CT.
考虑到化疗（CT）的不良反应的影响以及饮食对患者康复的潜在影响，本研究旨在前瞻性评估食物组的消耗、患者的饮食炎症指数（DII）评分及其营养状况之间的关系。对 55 名乳腺癌（BC）女性在三个时间点进行了人体测量和饮食评估。T0 是第一个 CT 周期后的时间点，T1 是中间 CT 周期后的时间点，T2 是最后一个 CT 周期后的时间点。我们发现 CT 期间体重、体重指数和腰围显著增加。与 T2 相比，T1 时家禽和鸡蛋的消耗量较高，而 T0 时总水果和总蔬菜的消耗量较高。饮食在治疗过程中变得更加促炎（X = 61.127），并与腹部肥胖程度增加有关。总水果（T0：R = 0.208，T1：R = 0.095，T2：R = 0.120）和总蔬菜摄入量（T0：R = 0.284，T1：R = 0.365，T2：R = 0.580）可预测三个时间点的 DII 变化。同时，总谷物的消耗仅与 T1（R = 0.084）和 T2（R = 0.118）显著相关，而简单糖的消耗仅与 T0（R = 0.137）和 T1（R = 0.126）显著相关。食物消耗的变化导致饮食的炎症特征增加，表明有必要在 CT 期间和之后改进指南。这些结果强化了在接受 CT 治疗的 BC 女性中促进更健康的饮食实践与保持健康营养状况的必要性。
