Cai Haobin, Wang Yijie, He Jiayang, Cai Tiantian, Wu Jun, Fang Jiansong, Zhang Rong, Guo Zhouke, Guan Li, Zhan Qinkai, Lin Li, Xiao Yao, Pan Huafeng, Wang Qi
Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
Department of Neurology & Psychology, Shenzhen Hospital Affiliated to Guangzhou University of Chinese Medicine, Shenzhen 518033, China.
Oncotarget. 2017 Oct 4;8(54):92621-92634. doi: 10.18632/oncotarget.21515. eCollection 2017 Nov 3.
Alzheimer's disease (AD) is a progressive neurological degenerative disease. The main clinical manifestations of AD include progressive cognitive impairment and alteration of personality. Senile plaques, neuroinflammation, and destruction of synapse structure stability are the main pathological features of AD. Bajijiasu(BJJS) is extracted from Morinda Officinalis, a Chinese herb. In this study, we explored the effect of BJJS on AD from many aspects in APPswe/PSEN1ΔE9 (APP/PS1) double transgenic mice. The Morris water maze and novel object recognition tests results showed that BJJS could significantly improve the learning and memory abilities in APP/PS1 mice. BJJS treatment increased the level of insulin degradation enzyme (IDE) and neprilysin (NEP) and decreased the level of β-site app cleaving enzyme 1(BACE1) in the brain of APP/PS1 mice. BJJS-treated APP/PS1 mice appeared to have reductions of Aβ deposition and senile plaques, and showed higher levels of neurotrophic factors in the brain. We also found that BJJS had an inhibitory function on neuroinflammation in APP/PS1 mice. In addition, the synapse structure relevant proteins were elevated in the brain of BJJS-treated APP/PS1 mice. The present results indicated that BJJS could attenuate cognitive impairment via ameliorating the AD-related pathological alterations in APP/PS1 mice. These findings suggest that BJJS may be a potential therapeutic strategy in Alzheimer's disease.
阿尔茨海默病（AD）是一种进行性神经退行性疾病。AD的主要临床表现包括进行性认知障碍和人格改变。老年斑、神经炎症以及突触结构稳定性破坏是AD的主要病理特征。巴戟甲素（BJJS）是从一种中药材巴戟天中提取的。在本研究中，我们从多个方面探讨了BJJS对APPswe/PSEN1ΔE9（APP/PS1）双转基因小鼠AD的影响。莫里斯水迷宫和新物体识别测试结果表明，BJJS可显著改善APP/PS1小鼠的学习和记忆能力。BJJS处理可提高APP/PS1小鼠大脑中胰岛素降解酶（IDE）和中性内肽酶（NEP）的水平，并降低β-淀粉样前体蛋白裂解酶1（BACE1）的水平。BJJS处理的APP/PS1小鼠的Aβ沉积和老年斑似乎减少，且大脑中神经营养因子水平较高。我们还发现BJJS对APP/PS1小鼠的神经炎症具有抑制作用。此外，BJJS处理的APP/PS1小鼠大脑中与突触结构相关的蛋白质水平升高。目前的结果表明，BJJS可通过改善APP/PS1小鼠中与AD相关的病理改变来减轻认知障碍。这些发现表明BJJS可能是阿尔茨海默病的一种潜在治疗策略。
