血清铁蛋白与原发性肺癌
Serum ferritin and primary lung cancer.
作者信息
Chen Zhongqing, Zhu Bo, Ou Chao, Li Yuxuan
机构信息
Department of Clinical Laboratory, Guangxi Medical University Affiliated Tumor Hospital, Nanning 530021, Guangxi Province, P.R. China.
Experimental Research Department, Guangxi Medical University Affiliated Tumor Hospital, Nanning 530021, Guangxi Province, P.R. China.
出版信息
Oncotarget. 2017 Oct 4;8(54):92643-92651. doi: 10.18632/oncotarget.21518. eCollection 2017 Nov 3.
Existing research yields conflicting results regarding the relation between iron deficiency and high serum ferritin (SF) levels in primary lung cancer patients. We investigated the concentrations of SF, hemoglobin (Hb) and transferrin (TRF) in 569 male primary lung cancer patients and 252 female primary lung cancer patients. We grouped the subjects according to gender, smoking status, menopausal status, pathological type, stage, and TNM stage. The levels of SF and TRF were correlated with T stage in male patients (). The levels of SF and TRF were correlated with menopausal status in female patients (). Hb was correlated with smoking status, pathological type, stage, and TNM stages in male patients(), but in female patients, Hb was not correlated with these grouping factors(). The levels of SF may be regulated by different mechanisms and may be of different physiological significance in different populations.
现有研究对于原发性肺癌患者缺铁与高血清铁蛋白（SF）水平之间的关系得出了相互矛盾的结果。我们调查了569例男性原发性肺癌患者和252例女性原发性肺癌患者的SF、血红蛋白（Hb）和转铁蛋白（TRF）浓度。我们根据性别、吸烟状况、绝经状态、病理类型、分期和TNM分期对研究对象进行分组。男性患者中SF和TRF水平与T分期相关（）。女性患者中SF和TRF水平与绝经状态相关（）。男性患者中Hb与吸烟状况、病理类型、分期和TNM分期相关（），但在女性患者中，Hb与这些分组因素无关（）。SF水平可能受不同机制调节，在不同人群中可能具有不同的生理意义。
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