Ye Zhimin, Fang Jun, Dai Shujun, Xie Tieming, Wang Fangzheng, Wang Zhun, Li Kai, Fu Zhenfu, Wang Yuezhen
Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China.
Department of Intensive Care Unit, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Oncotarget. 2017 Oct 6;8(54):92880-92889. doi: 10.18632/oncotarget.21639. eCollection 2017 Nov 3.
The apparent diffuse coefficient (ADC) may correlate with the treatment response to chemotherapy/radiotherapy in solid tumors. Our aim was to determine the inter- and intra-observer reproducibility of ADC measurements in primary esophageal squamous cell carcinoma (ESCC). ADCs were blindly measured in 31 patients diagnosed with ESCC by two observers before treatment (pre-ADC) and after 5 fraction radiotherapy (intra-ADC) twice with a 2-week interval. The mean pre-ADC of primary tumors was 1.25±0.22 and 1.27±0.23 (in 10mm/s) from observer A for measurements 1 and 2, respectively, and the intra-observer measurements were -0.02 bias vs. -0.13-0.09 limits of agreement. From observer B, the mean pre-ADC varied between 1.25±0.23 and 1.27±0.23 (in 10mm/s) for measurements 1 and 2, respectively, and intra-observer measurements were -0.02 bias vs. -0.17∼0.16 limits of agreement. The mean pre-ADC of primary tumors was 1.26±0.24 (in 10mm/s) from observers A and B, and inter-observer measurements were 0.01 bias vs. -0.09-0.09 limits of agreement, revealing a low inter-observer variance. Similar measurements of the intra-SD parameters showed that the pre- and intra-ADC of primary tumors differed significantly. Thus ADC measurements may have sufficient inter-observer and intra-observer reproducibility to measure primary tumor responses to treatment, and the ADCs before and during treatment differed.
表观扩散系数（ADC）可能与实体瘤化疗/放疗的治疗反应相关。我们的目的是确定原发性食管鳞状细胞癌（ESCC）中ADC测量的观察者间和观察者内的可重复性。在31例经诊断为ESCC的患者中，由两名观察者在治疗前（预ADC）和5次分割放疗后（放疗中ADC）进行两次ADC测量，间隔2周。观察者A对原发性肿瘤的预ADC平均值在测量1和测量2时分别为1.25±0.22和1.27±0.23（单位：10mm/s），观察者内测量的偏倚为-0.02，一致性界限为-0.13至-0.09。观察者B的预ADC平均值在测量1和测量2时分别在1.25±0.23和1.27±0.23（单位：10mm/s）之间，观察者内测量的偏倚为-0.02，一致性界限为-0.17至0.16。观察者A和B测得的原发性肿瘤预ADC平均值为1.26±0.24（单位：10mm/s），观察者间测量的偏倚为0.01，一致性界限为-0.09至0.09，显示观察者间差异较小。对瘤内标准差参数的类似测量表明，原发性肿瘤的预ADC和放疗中ADC有显著差异。因此，ADC测量在测量原发性肿瘤对治疗的反应方面可能具有足够的观察者间和观察者内可重复性，并且治疗前和治疗期间的ADC有所不同。
