IEEE Trans Med Imaging. 2017 Dec;36(12):2569-2577. doi: 10.1109/TMI.2017.2766101.
Repeated CT scans are known to increase the risk of cancer; thus, it is paradoxical to use multiple follow-up CT scans to monitor the development of a lung nodule and conduct early treatment of the nodule. In the case of a solitary lung nodule, regional scanning and region of interest (ROI) reconstruction are likely to restore the internal area at the nodule. A limited-range few-view CT is proposed in this paper for lung nodule follow-ups with extremely reduced X-radiation. For a planned scanning of an ROI, where a solitary lung nodule is positioned, a limited-range few-view CT can be employed, and thus, less tissue is exposed to X-radiation per view. An ROI reconstruction method is also proposed that makes full use of the former standard lung scan. The experimental results show that the nodule size and shape are preserved. In the case of a 40-mm ROI, the number of exposed X-rays can be reduced by 99.6% for a circular scan and 99.9% for a 3-D scan.
重复的 CT 扫描已知会增加癌症风险；因此，使用多次随访 CT 扫描来监测肺结节的发展并进行早期治疗是自相矛盾的。对于孤立性肺结节，可以进行区域扫描和感兴趣区域（ROI）重建，以恢复结节内部区域。本文提出了一种用于肺结节随访的有限范围少视图 CT，可极大减少 X 射线辐射。对于计划对包含孤立性肺结节的 ROI 进行扫描，可以使用有限范围少视图 CT，从而使每幅图像暴露的组织更少。本文还提出了一种 ROI 重建方法，可充分利用先前的标准肺部扫描。实验结果表明，结节的大小和形状得以保留。对于 40mm 的 ROI，圆形扫描可将 X 射线暴露量减少 99.6%，3D 扫描可减少 99.9%。
