热力学耐药性的秘密：对次级主动转运体转运机制的新认识。
Thermodynamic secrets of multidrug resistance: A new take on transport mechanisms of secondary active antiporters.
机构信息
National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing, 100101, China.
College of Life Science, University of Chinese Academy of Sciences, Beijing, 100049, China.
出版信息
Protein Sci. 2018 Mar;27(3):595-613. doi: 10.1002/pro.3355. Epub 2017 Dec 15.
Abstract
Multidrug resistance (MDR) presents a growing challenge to global public health. Drug extrusion transporters play a critical part in MDR; thus, their mechanisms of substrate recognition are being studied in great detail. In this work, we review common structural features of key transporters involved in MDR. Based on our membrane potential-driving hypothesis, we propose a general energy-coupling mechanism for secondary-active antiporters. This putative mechanism provides a common framework for understanding poly-specificity of most-if not all-MDR transporters.
摘要
多药耐药性（MDR）对全球公共健康构成了日益严峻的挑战。药物外排转运蛋白在 MDR 中起着至关重要的作用；因此，它们对底物的识别机制正在被深入研究。在这项工作中，我们回顾了参与 MDR 的关键转运蛋白的常见结构特征。基于我们的膜电位驱动假说，我们提出了一种用于次级主动转运蛋白的通用能量耦联机制。该假设机制为理解大多数（如果不是全部）MDR 转运蛋白的多特异性提供了一个通用框架。
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