Department of Surgery and Cancer, Imperial College London, London, UK.
Ann Surg. 2019 May;269(5):903-910. doi: 10.1097/SLA.0000000000002539.
BACKGROUND:: Breath VOCs have the potential to noninvasively diagnose cancer.
Exhaled breath samples were collected using 2-L double-layered Nalophan bags, and were analyzed using selected-ion-flow-tube mass-spectrometry. Gold-standard test for comparison was endoscopy for luminal inspection and computed tomography (CT) to confirm cancer recurrence. Three studies were conducted: RESULTS:: CONCLUSION:: This study suggests the association of a single breath biomarker with the primary presence and recurrence of CRCa. Further multicenter validation studies are required to validate these findings.
背景：呼吸挥发性有机化合物有可能进行非侵入性诊断癌症。
使用 2 升双层 Nalophan 袋收集呼气样本，并使用选择离子流管质谱进行分析。比较的金标准测试是内窥镜检查腔内检查和计算机断层扫描 (CT) 以确认癌症复发。进行了三项研究：结果：结论：本研究表明单个呼吸生物标志物与 CRCa 的主要存在和复发有关。需要进行更多的多中心验证研究来验证这些发现。
