采用选择离子流管质谱法对结直肠癌的呼吸挥发性有机化合物进行分析。
Breath Volatile Organic Compound Profiling of Colorectal Cancer Using Selected Ion Flow-tube Mass Spectrometry.
机构信息
Department of Surgery and Cancer, Imperial College London, London, UK.
出版信息
Ann Surg. 2019 May;269(5):903-910. doi: 10.1097/SLA.0000000000002539.
OBJECTIVE
BACKGROUND:: Breath VOCs have the potential to noninvasively diagnose cancer.
METHODS
Exhaled breath samples were collected using 2-L double-layered Nalophan bags, and were analyzed using selected-ion-flow-tube mass-spectrometry. Gold-standard test for comparison was endoscopy for luminal inspection and computed tomography (CT) to confirm cancer recurrence. Three studies were conducted: RESULTS:: CONCLUSION:: This study suggests the association of a single breath biomarker with the primary presence and recurrence of CRCa. Further multicenter validation studies are required to validate these findings.
目的
背景：呼吸挥发性有机化合物有可能进行非侵入性诊断癌症。
方法
使用 2 升双层 Nalophan 袋收集呼气样本，并使用选择离子流管质谱进行分析。比较的金标准测试是内窥镜检查腔内检查和计算机断层扫描 (CT) 以确认癌症复发。进行了三项研究：结果：结论：本研究表明单个呼吸生物标志物与 CRCa 的主要存在和复发有关。需要进行更多的多中心验证研究来验证这些发现。
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