Department of Dermatology, Leeds Teaching Hospitals NHS Trust, Leeds, LS7 4SA, UK.
Clinica Dermatologica, Department of Health Sciences (DiSSAL), Università di Genova, Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Contact Dermatitis. 2018 Feb;78(2):101-108. doi: 10.1111/cod.12918. Epub 2017 Dec 1.
The current European baseline series consists of 30 allergens, and was last updated in 2015.
To use data from the European Surveillance System on Contact Allergies (ESSCA) to propose an extension to the European baseline series in response to changes in environmental exposures.
Data from departmental and national extensions to the baseline series, together with some temporary additions from departments contributing to the ESSCA, were collated during 2013-2014.
In total, 31689 patients were patch tested in 46 European departments. Many departments and national groups already consider the current European baseline series to be a suboptimal screen, and use their own extensions to it. The haptens tested are heterogeneous, although there are some consistent themes. Potential haptens to include in an extension to the European baseline series comprise sodium metabisulfite, formaldehyde-releasing preservatives, additional markers of fragrance allergy, propolis, Compositae mix, and 2-hydroxyethyl methacrylate.
In combination with other published work from the ESSCA, changes to the current European baseline series are proposed for discussion. As well as addition of the allergens listed above, it is suggested that primin and clioquinol should be deleted from the series, owing to reduced environmental exposure.
当前的欧洲基准系列包含 30 种过敏原，最后一次更新是在 2015 年。
利用欧洲接触性过敏监测系统（ESSCA）的数据，针对环境暴露的变化，提出对欧洲基准系列的扩展。
在 2013-2014 年期间，收集了基准系列部门和国家扩展的数据，以及一些来自参与 ESSCA 的部门的临时添加数据。
在 46 个欧洲部门中，共有 31689 名患者接受了斑贴试验。许多部门和国家团体已经认为当前的欧洲基准系列是一种次优的筛查方法，并使用自己的扩展版本。所测试的半抗原具有异质性，尽管存在一些一致的主题。潜在的要包含在欧洲基准系列扩展中的半抗原包括亚硫酸钠、释放甲醛的防腐剂、香料过敏的额外标志物、蜂胶、菊科混合物和 2-羟乙基甲基丙烯酸酯。
结合 ESSCA 的其他已发表工作，提出了对当前欧洲基准系列的修改建议，以供讨论。除了上述过敏原之外，由于环境暴露减少，建议从该系列中删除普瑞马林和氯喹醇。
