Ljuba Vujanović, Sanja Jakovljević, Zoran Golušin, Olivera Levakov
Departments of Dermatovenereology, Faculty of Medicine Novi Sad, University of Novi Sad, Clinic of Dermatovenereology Diseases, Clinical Centre of Vojvodina, Novi Sad, Serbia.
Indian J Dermatol. 2022 Sep-Oct;67(5):625. doi: 10.4103/ijd.ijd_705_21.
The use of alternative treatment methods, particularly medicinal herbs from the family Compositae, significantly contributes to the increase in the incidence of allergic contact dermatitis among patients with chronic venous insufficiency.
Estimating frequency of contact sensitization among patients with chronic venous insufficiency and determining the most common contact sensitizers from the series of bio-origin allergens from the Compositae family and ubiquitous weeds of Vojvodina.
The total number of 266 patients with suspected contact dermatitis was divided into two groups: the experimental group consisted of patients with chronic venous insufficiency (EG), and the control group consisted of patients without chronic venous insufficiency (CG). All subjects were tested with allergens of biological origin from the family Compositae, screening allergen SL-mix and original extracts of ubiquitous weed plants of Vojvodina.
Patch test revealed a positive reaction to allergens of the Compositae family in 6.69% in the experimental group, and in 4.17% in the control group. The standardized response rate to the SL-mix in the experimental group was 2.07%, while in the control group, it was 1.51%. The presence of a positive reaction to at least one extract of ubiquitous weed plants of Vojvodina was determined in 6.11% in the experimental group, and in 3.23% of patients in the control group. No statistically significant difference in response rates was found between the examined groups.
Establishing the diagnosis of Compositae dermatitis can be supplemented by additional testing with weed plant extracts from a specific geographical area, resulting in the detection of novel unknown allergens.
使用替代治疗方法，尤其是菊科药用植物，显著导致慢性静脉功能不全患者中过敏性接触性皮炎发病率增加。
估计慢性静脉功能不全患者中接触致敏的频率，并确定菊科生物源过敏原系列以及伏伊伏丁那常见杂草中最常见的接触致敏原。
266例疑似接触性皮炎患者被分为两组：实验组由慢性静脉功能不全患者（EG）组成，对照组由无慢性静脉功能不全患者（CG）组成。所有受试者均用菊科生物源过敏原、筛选过敏原SL - mix以及伏伊伏丁那常见杂草植物的原始提取物进行检测。
斑贴试验显示，实验组中对菊科过敏原的阳性反应率为6.69%，对照组为4.17%。实验组对SL - mix的标准化反应率为2.07%，而对照组为1.51%。实验组中6.11%的患者对伏伊伏丁那至少一种常见杂草植物提取物呈阳性反应，对照组为3.23%。在各检测组之间未发现反应率有统计学显著差异。
通过对特定地理区域杂草植物提取物进行额外检测，可以补充菊科皮炎的诊断，从而检测到新的未知过敏原。
