Aron N B, Feinfeld D A, Peters A T, Lynn R I
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.
Am J Kidney Dis. 1989 Mar;13(3):189-93. doi: 10.1016/s0272-6386(89)80051-4.
Iodinated radiocontrast agents may cause acute renal failure, particularly in patients with preexisting renal failure, heart failure, or diabetes. The low-osmolality contrast agents cause less hypersensitivity, but substantial nephrotoxicity has not been noted. We report three high-risk patients who developed acute renal failure after one of these new agents, ioxaglate, was administered for coronary arteriography and ventriculography. The renal failure was severe: two of the patients required dialysis. We could find no previously reported cases of acute renal failure associated with ioxaglate. Despite their theoretical advantages, the low-osmolality contrast agents may cause acute renal failure in patients who are at risk and should be used with the same precautions as the conventional agents.
含碘造影剂可能导致急性肾衰竭，尤其是在已有肾衰竭、心力衰竭或糖尿病的患者中。低渗造影剂引起的过敏反应较少，但尚未发现明显的肾毒性。我们报告了3例高危患者，在使用其中一种新型造影剂碘克沙醇进行冠状动脉造影和心室造影后发生了急性肾衰竭。肾衰竭很严重：其中2例患者需要透析。我们未发现之前有与碘克沙醇相关的急性肾衰竭病例报告。尽管低渗造影剂具有理论上的优势，但在高危患者中仍可能导致急性肾衰竭，使用时应与传统造影剂一样采取相同的预防措施。
