Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Germany.
Division of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, The Netherlands.
Trends Immunol. 2018 Feb;39(2):151-162. doi: 10.1016/j.it.2017.10.005. Epub 2017 Nov 28.
Mast cells (MCs) contribute to the pathogenesis of a multitude of diseases that include MC-driven disorders such as urticaria, type I allergies, and mastocytosis as well as autoimmune and other inflammatory disorders and malignant tumors. Here, we review and discuss the results of studies that identified and characterized how MCs contribute to disease and, importantly, what strategies may be used to target MCs and MC effects therapeutically. Specifically, we discuss the most common approaches for investigating the role and relevance of MCs in various diseases. We also review current therapeutic approaches aimed at modulating MC numbers, inhibiting MCs and/or preventing MC activation, modulating MC signal transduction and protection from the effects of MC mediators.
肥大细胞（MCs）参与多种疾病的发病机制，包括 MC 驱动的疾病，如荨麻疹、I 型过敏和肥大细胞增多症，以及自身免疫和其他炎症性疾病和恶性肿瘤。在这里，我们回顾和讨论了确定和描述 MC 如何导致疾病的研究结果，以及重要的是，哪些策略可用于针对 MC 和 MC 作用进行治疗。具体来说，我们讨论了研究 MC 在各种疾病中的作用和相关性的最常见方法。我们还回顾了目前旨在调节 MC 数量、抑制 MC 和/或防止 MC 激活、调节 MC 信号转导和防止 MC 介质影响的治疗方法。
